Detailed information of TA system TA099822

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1004592..1005112
• Replicon: chromosome
• Accession: NZ_CP027667
• Organism: Melaminivora sp. SC2-9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C6568_RS04755
• Protein ID: WP_106683131.1
• Coordinates: 1004828..1005112 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C6568_RS04750
• Protein ID: WP_106683130.1
• Coordinates: 1004592..1004825 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6568_RS04685	999749..1000126	+	378	WP_106685342.1	type II toxin-antitoxin system RelE/ParE family toxin	-
C6568_RS04690	1000110..1000445	+	336	WP_106683122.1	helix-turn-helix domain-containing protein	-
C6568_RS04700	1000671..1001043	+	373	Protein_915	MarR family transcriptional regulator	-
C6568_RS04705	1001139..1001411	+	273	WP_106683123.1	helix-turn-helix domain-containing protein	-
C6568_RS04710	1001408..1001689	+	282	WP_106683124.1	hypothetical protein	-
C6568_RS04715	1001676..1001996	+	321	WP_106683125.1	hypothetical protein	-
C6568_RS04720	1002142..1002333	+	192	WP_106683126.1	DUF4160 domain-containing protein	-
C6568_RS04725	1002330..1002830	+	501	WP_106683127.1	DUF2442 domain-containing protein	-
C6568_RS04730	1003031..1003348	+	318	WP_106683128.1	type II toxin-antitoxin system RelE/ParE family toxin	-
C6568_RS04735	1003370..1003675	+	306	WP_106685343.1	addiction module antidote protein	-
C6568_RS17810	1003853..1003999	+	147	WP_158702842.1	hypothetical protein	-
C6568_RS04740	1004006..1004230	-	225	WP_199792856.1	hypothetical protein	-
C6568_RS04745	1004178..1004441	+	264	WP_106683129.1	helix-turn-helix transcriptional regulator	-
C6568_RS04750	1004592..1004825	+	234	WP_106683130.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
C6568_RS04755	1004828..1005112	+	285	WP_106683131.1	type II toxin-antitoxin system YafQ family toxin	Toxin
C6568_RS04760	1005171..1005497	+	327	WP_106683132.1	DUF2442 domain-containing protein	-
C6568_RS17815	1005894..1006031	+	138	WP_158702843.1	hypothetical protein	-
C6568_RS04770	1006120..1007676	-	1557	WP_106683133.1	methyltransferase regulatory domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-94)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-68)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10777.33 Da
• Isoelectric Point: 9.6550

>T99822 WP_106683131.1 NZ_CP027667:1004828-1005112 [Melaminivora sp. SC2-9]
VTRTLEETSQFKRDKKRIKGSGRHDWGKIRAVVVELMNDRPLAPKHRDHDLVGDYVGVRECHVTPDWLLIYDKEGPLATG
SLKLIRTGSHSELF

Nucleotide

• Length: 285 bp

>T99822 NZ_CP027667:1004828-1005112 [Melaminivora sp. SC2-9]
GTGACCCGTACCCTGGAAGAAACCAGCCAGTTCAAGCGCGATAAAAAACGTATCAAAGGCTCGGGGCGCCACGACTGGGG
CAAGATCCGGGCTGTCGTTGTAGAACTGATGAACGACCGGCCCCTGGCGCCGAAACATCGTGACCACGATTTGGTGGGCG
ACTACGTCGGAGTGCGTGAGTGCCACGTCACGCCTGATTGGCTGCTCATCTATGACAAGGAGGGGCCGCTCGCCACGGGT
TCGCTCAAGCTCATCCGCACCGGCTCGCACAGCGAACTATTTTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8315.66 Da
• Isoelectric Point: 6.3084

>AT99822 WP_106683130.1 NZ_CP027667:1004592-1004825 [Melaminivora sp. SC2-9]
MLTADVRSRVEPELKREAAAVLKASGLDLSTAIRLFLRSVVEQGGLPMEMPRPNADTLAAIREAKEGRATPVPLADF

Nucleotide

• Length: 234 bp

>AT99822 NZ_CP027667:1004592-1004825 [Melaminivora sp. SC2-9]
ATGTTGACTGCTGACGTTCGCTCCCGCGTGGAGCCCGAGCTCAAGCGCGAGGCGGCGGCTGTGCTCAAGGCTTCTGGCCT
GGACCTGAGCACCGCCATCCGTCTTTTTTTGCGCAGCGTCGTGGAGCAAGGCGGCCTGCCCATGGAGATGCCTCGCCCCA
ACGCTGACACCTTGGCGGCCATTCGCGAAGCCAAGGAGGGCCGGGCGACGCCTGTCCCCCTGGCGGACTTTTGA