Detailed information of TA system TA099821

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 630551..631149
• Replicon: chromosome
• Accession: NZ_CP027667
• Organism: Melaminivora sp. SC2-9

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: C6568_RS02915
• Protein ID: WP_106682797.1
• Coordinates: 630892..631149 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C6568_RS02910
• Protein ID: WP_106685318.1
• Coordinates: 630551..630886 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6568_RS02900	625750..626874	+	1125	WP_106682795.1	formylglycine-generating enzyme family protein	-
C6568_RS02905	626883..630458	-	3576	WP_106682796.1	class I SAM-dependent DNA methyltransferase	-
C6568_RS02910	630551..630886	-	336	WP_106685318.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C6568_RS02915	630892..631149	-	258	WP_106682797.1	type II toxin-antitoxin system HicA family toxin	Toxin
C6568_RS02920	631186..632556	-	1371	WP_106682798.1	tryptophanase	-
C6568_RS17945	632770..633768	+	999	WP_106682799.1	J domain-containing protein	-
C6568_RS02930	633921..634859	+	939	WP_106682800.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (24-82)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9468.01 Da
• Isoelectric Point: 10.0130

>T99821 WP_106682797.1 NZ_CP027667:c631149-630892 [Melaminivora sp. SC2-9]
MQRKYAKTLALLFHRPVSANVRHDEVMALLRQLGAEIEAGREGSRIAVVLFGQVRVFHKPHPSPHMDKGAVAALCDWLEQ
NGVTP

Nucleotide

• Length: 258 bp

>T99821 NZ_CP027667:c631149-630892 [Melaminivora sp. SC2-9]
ATGCAGCGCAAATATGCCAAAACCCTCGCATTGCTGTTTCACCGTCCGGTGTCTGCAAACGTGCGGCATGACGAGGTCAT
GGCATTGCTTCGGCAGCTCGGGGCTGAAATCGAGGCGGGGCGAGAGGGCTCGCGCATAGCCGTCGTGCTGTTCGGGCAAG
TGCGCGTTTTCCACAAACCGCATCCGTCACCGCACATGGACAAAGGCGCGGTGGCAGCCCTATGCGACTGGTTGGAACAA
AACGGAGTCACGCCATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12272.92 Da
• Isoelectric Point: 6.7108

>AT99821 WP_106685318.1 NZ_CP027667:c630886-630551 [Melaminivora sp. SC2-9]
MNTMELDGYTAVIQYNPQTDEFRGEIQGLNGGADFYGKTPDELRREFRASLDFFLQTCAKHGIEPRKSVSGKFMVRVSPE
LHARAAAAAMACGISLNALVERALRHEVQPG

Nucleotide

• Length: 336 bp

>AT99821 NZ_CP027667:c630886-630551 [Melaminivora sp. SC2-9]
ATGAACACGATGGAGCTGGACGGCTACACCGCCGTCATCCAATACAACCCACAGACTGACGAATTCCGGGGAGAAATCCA
GGGCTTGAATGGTGGCGCCGACTTCTACGGCAAGACGCCCGACGAGTTGCGCCGCGAGTTCCGTGCCTCACTAGATTTCT
TTTTGCAAACGTGCGCCAAGCATGGCATCGAGCCGCGCAAGAGCGTCAGCGGCAAGTTCATGGTGCGCGTCTCTCCGGAG
CTGCACGCACGCGCTGCCGCCGCAGCCATGGCTTGCGGCATCAGCCTGAATGCGCTGGTGGAGCGCGCTTTGCGTCATGA
AGTCCAGCCCGGCTGA