Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1505434..1506991 Replicon chromosome
Accession NZ_CP027665
Organism Pukyongiella litopenaei strain SH-1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag C6Y53_RS07635 Protein ID WP_106471893.1
Coordinates 1505687..1506991 (+) Length 435 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag C6Y53_RS07630 Protein ID WP_106471892.1
Coordinates 1505434..1505685 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6Y53_RS07595 (C6Y53_07540) 1501274..1501753 + 480 WP_106471887.1 hypothetical protein -
C6Y53_RS07600 (C6Y53_18960) 1501768..1502304 + 537 WP_149615494.1 hypothetical protein -
C6Y53_RS07605 (C6Y53_07545) 1502341..1503555 + 1215 WP_106471888.1 IS256 family transposase -
C6Y53_RS07610 (C6Y53_18965) 1503516..1503839 - 324 WP_149615495.1 hypothetical protein -
C6Y53_RS07615 (C6Y53_07550) 1504005..1504292 - 288 WP_106471889.1 hypothetical protein -
C6Y53_RS07620 (C6Y53_07555) 1504289..1504525 - 237 WP_106471890.1 hypothetical protein -
C6Y53_RS21360 1504804..1504926 + 123 WP_280178365.1 hypothetical protein -
C6Y53_RS07625 (C6Y53_07560) 1505069..1505248 + 180 WP_106471891.1 hypothetical protein -
C6Y53_RS07630 (C6Y53_07565) 1505434..1505685 + 252 WP_106471892.1 helix-turn-helix transcriptional regulator Antitoxin
C6Y53_RS07635 (C6Y53_07570) 1505687..1506991 + 1305 WP_106471893.1 type II toxin-antitoxin system HipA family toxin Toxin
C6Y53_RS07640 (C6Y53_07575) 1507117..1507776 - 660 WP_244614973.1 zincin-like metallopeptidase domain-containing protein -
C6Y53_RS07645 (C6Y53_07580) 1507813..1508526 + 714 WP_211299546.1 hypothetical protein -
C6Y53_RS07650 (C6Y53_18970) 1508529..1509065 + 537 WP_149615496.1 hypothetical protein -
C6Y53_RS07655 (C6Y53_07585) 1509065..1511023 + 1959 WP_149615497.1 type IV secretory system conjugative DNA transfer family protein -
C6Y53_RS07660 (C6Y53_18975) 1511159..1511353 + 195 WP_149615498.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 435 a.a.        Molecular weight: 47935.89 Da        Isoelectric Point: 6.4239

>T99819 WP_106471893.1 NZ_CP027665:1505687-1506991 [Pukyongiella litopenaei]
MGRKRSYPPLNVFLNARHVGQLLRESTGAISFVYDQDWLAWEHRLPVSLSLPLREDRYVGAPVIAVFENLLPDNDVIRRR
VAERVGAAGTDAYSLLSEIGRDCVGALQFLPDGEEPQAADDLTGHPVSETDIEALLGELDVAPLGIRREKDFRISVAGAQ
EKTALLWHDGKWLEPSGTTPTTHIIKPQIGRLPNGMDLSNSVENEYLCLKLMEGFGLRAANIGMASFGARKALVIERFDR
LWTKDGRLIRLPQEDCAQALSVPPTQKYQNEGGPGIAEIMGLLLGSDEPVQDRLDFFKANILFWLSGATDGHAKNFSLAL
MPGGRFRLTPFYDVLTVQPTLDANQLNRKDFKLAMRFGKSNHYKVGDIIGRHIMETGVESGLSRKAIADLFDDIQASAKA
AMDKTFAALPAGFPEVLVTSIRSAVLDRLRHLKP

Download         Length: 1305 bp

>T99819 NZ_CP027665:1505687-1506991 [Pukyongiella litopenaei]
ATGGGACGCAAACGAAGCTATCCGCCGCTAAATGTCTTTCTAAATGCGCGCCATGTTGGCCAACTCCTGCGCGAAAGCAC
GGGCGCGATCAGCTTTGTCTATGATCAAGACTGGCTGGCTTGGGAGCACCGCTTGCCAGTGTCCCTGTCACTTCCACTGC
GAGAAGATCGTTATGTCGGCGCGCCTGTCATAGCCGTTTTCGAAAATCTGCTACCGGACAATGATGTTATCAGACGGCGC
GTTGCCGAGCGCGTTGGCGCGGCGGGCACGGACGCCTACAGCCTGCTAAGCGAAATTGGCCGCGACTGTGTGGGCGCGCT
TCAATTCTTGCCGGACGGTGAAGAACCGCAAGCCGCCGACGATCTCACCGGTCATCCGGTCAGTGAGACGGACATCGAGG
CGCTGCTGGGTGAGCTCGACGTCGCACCGCTCGGCATCAGGAGAGAAAAAGACTTCCGGATATCGGTGGCAGGCGCACAG
GAAAAAACTGCCCTGCTCTGGCATGACGGCAAGTGGTTAGAGCCTTCGGGCACAACACCGACAACGCATATCATCAAGCC
GCAGATCGGACGGCTCCCCAATGGCATGGATTTGTCGAACAGCGTCGAGAATGAATATCTGTGCCTGAAACTGATGGAAG
GCTTTGGCCTGCGCGCCGCAAATATCGGAATGGCCAGCTTCGGCGCGCGCAAGGCTCTTGTTATCGAGCGGTTTGACCGG
CTCTGGACGAAGGATGGCCGCCTCATCCGCTTGCCGCAAGAAGACTGCGCGCAAGCCCTATCAGTGCCGCCGACACAGAA
ATACCAGAATGAAGGCGGGCCAGGTATCGCCGAAATCATGGGGCTCTTGCTCGGAAGTGACGAGCCCGTGCAAGATCGAC
TAGATTTCTTCAAAGCCAATATCTTGTTCTGGCTGAGCGGGGCCACCGATGGGCATGCCAAGAATTTCAGTCTCGCCTTG
ATGCCAGGCGGACGTTTCCGGCTAACGCCATTTTATGACGTGCTGACCGTTCAACCGACATTGGATGCTAACCAACTGAA
CAGAAAAGACTTCAAGCTCGCCATGCGCTTTGGCAAGTCTAATCACTACAAGGTCGGCGATATCATTGGGCGGCACATCA
TGGAGACCGGAGTTGAGTCCGGCCTGTCCCGCAAAGCCATTGCCGATCTTTTTGACGATATCCAAGCATCCGCCAAGGCC
GCTATGGACAAAACCTTCGCTGCACTTCCCGCAGGATTTCCAGAAGTGCTTGTCACTTCGATCCGCAGCGCGGTCTTGGA
CCGCCTACGCCACCTCAAACCTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.55 Da        Isoelectric Point: 8.7070

>AT99819 WP_106471892.1 NZ_CP027665:1505434-1505685 [Pukyongiella litopenaei]
MKNLARTPNDIGHAIRQARKAKKLTQKELAERSGVWQETVSKVENGLSGTKLETIFDIFAALDLEIQVQSRSKGSTESFE
DIF

Download         Length: 252 bp

>AT99819 NZ_CP027665:1505434-1505685 [Pukyongiella litopenaei]
ATGAAGAACCTGGCACGCACACCAAACGATATCGGGCACGCCATCCGCCAAGCCCGTAAGGCAAAAAAGCTGACGCAGAA
AGAGCTCGCTGAGCGCAGCGGCGTCTGGCAGGAGACGGTTTCCAAGGTCGAGAACGGTTTGTCCGGCACCAAGCTGGAAA
CCATTTTCGATATCTTTGCCGCGCTCGACCTGGAAATTCAGGTGCAGAGCCGCAGCAAGGGCTCGACCGAGAGCTTCGAG
GACATCTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References