Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2988016..2989054 Replicon chromosome
Accession NZ_CP027663
Organism Acidiferrobacter sp. SPIII_3

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag C4901_RS15185 Protein ID WP_110138048.1
Coordinates 2988482..2989054 (+) Length 191 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag C4901_RS15180 Protein ID WP_110138047.1
Coordinates 2988016..2988477 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4901_RS15155 2984359..2984613 - 255 WP_110138042.1 BrnA antitoxin family protein -
C4901_RS15160 2984694..2984960 - 267 WP_110138043.1 BrnT family toxin -
C4901_RS15165 2985578..2985982 - 405 WP_168185760.1 DNA-binding protein -
C4901_RS15170 2986157..2987185 - 1029 WP_110138045.1 IS630 family transposase -
C4901_RS15175 2987216..2987863 + 648 WP_110138046.1 DUF4338 domain-containing protein -
C4901_RS15180 2988016..2988477 + 462 WP_110138047.1 helix-turn-helix domain-containing protein Antitoxin
C4901_RS15185 2988482..2989054 + 573 WP_110138048.1 PIN domain-containing protein Toxin
C4901_RS15190 2989169..2989963 + 795 WP_205736061.1 hypothetical protein -
C4901_RS15195 2989980..2991287 - 1308 WP_110138049.1 transposase -
C4901_RS15200 2991286..2991630 + 345 WP_110138050.1 IS200/IS605 family transposase -
C4901_RS18265 2991579..2991989 + 411 WP_205736062.1 IS200/IS605 family transposase -
C4901_RS15210 2992432..2993166 + 735 WP_110138051.1 ISAzo13 family transposase -
C4901_RS15215 2993114..2993887 + 774 WP_168185761.1 ISAzo13 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2983032..2984342 1310
- flank IS/Tn - - 2989980..2991269 1289


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-114)

Antitoxin

SinI-like, DNA-binding domain

(83-128)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 21297.39 Da        Isoelectric Point: 6.4024

>T99816 WP_110138048.1 NZ_CP027663:2988482-2989054 [Acidiferrobacter sp. SPIII_3]
MSSRFTVVYDACVLYPAPLRDLLMHLALSDLFRARWSELIHDEWTRNVLASRPDLTQDQLNRTRHLMNAHVRDSLVTGFE
YLIPSINLPDPDDRHVAAAAIHSGASLIVTFNLKDFPAEVLKPYNLAAQHPDDFIVDLLDPHPAGVLEAAASHRRSLKNP
PKTADGYLDILLAQGLTQSVALMRQWTVAM

Download         Length: 573 bp

>T99816 NZ_CP027663:2988482-2989054 [Acidiferrobacter sp. SPIII_3]
ATGAGTTCGCGCTTCACCGTCGTCTATGACGCTTGCGTCCTCTATCCGGCACCCCTGCGCGATCTGCTGATGCATCTGGC
GCTGTCGGATCTGTTCCGGGCGCGCTGGAGCGAACTGATCCACGATGAGTGGACGCGCAATGTCCTGGCCAGCCGACCTG
ATTTGACTCAAGACCAGTTGAACCGGACGCGCCACCTGATGAACGCCCACGTTCGGGACAGTTTGGTCACCGGATTCGAA
TACCTGATTCCGTCGATCAATCTGCCCGATCCGGACGACCGCCATGTGGCGGCGGCTGCCATCCACTCCGGCGCCAGCCT
GATCGTGACCTTCAACCTCAAGGACTTTCCGGCAGAGGTGCTCAAACCCTACAACCTCGCGGCTCAGCATCCGGACGACT
TCATCGTCGATCTCCTCGACCCGCATCCAGCAGGCGTACTGGAGGCCGCAGCCAGTCATCGGCGCTCACTGAAGAACCCG
CCCAAGACGGCGGACGGATATCTGGACATCCTGCTGGCGCAGGGCCTGACGCAATCGGTGGCGCTGATGCGCCAATGGAC
TGTGGCCATGTGA

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 17038.47 Da        Isoelectric Point: 6.4922

>AT99816 WP_110138047.1 NZ_CP027663:2988016-2988477 [Acidiferrobacter sp. SPIII_3]
MNAPAISKTLPSEEDIALARESSRVLSTVLQTRAETQQIDFHDDKGAVRAVRIPTSALRLLLEVLTEIGQGNAVSIIPIH
AELTTQEAADVLNISRPFLVQLLEKGDIPFHKIGTHRRVRYQDVITYKNRIDAERRKALDELAAQAQELGMGY

Download         Length: 462 bp

>AT99816 NZ_CP027663:2988016-2988477 [Acidiferrobacter sp. SPIII_3]
ATGAACGCTCCCGCTATCTCCAAAACACTGCCCTCCGAAGAGGACATCGCGCTCGCCCGGGAGTCGAGCCGTGTGCTGTC
GACTGTGCTCCAGACCCGCGCCGAAACCCAGCAGATCGACTTCCATGACGACAAGGGAGCGGTGCGCGCGGTGCGCATCC
CGACCTCGGCGCTGCGTCTGCTCCTGGAAGTCCTGACCGAGATCGGCCAGGGCAACGCCGTGTCGATCATTCCGATCCAC
GCTGAACTGACGACCCAGGAGGCGGCTGATGTTCTCAACATCTCGCGCCCCTTCCTTGTCCAACTGCTGGAGAAAGGCGA
CATCCCGTTCCACAAGATCGGCACCCACCGTCGTGTCCGCTACCAGGATGTGATCACCTACAAGAATCGCATCGATGCCG
AGCGTCGCAAGGCCCTGGATGAGCTGGCAGCACAGGCCCAGGAACTCGGCATGGGGTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References