Detailed information of TA system TA099815

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-CC2985
• Location: 2238132..2238660
• Replicon: chromosome
• Accession: NZ_CP027663
• Organism: Acidiferrobacter sp. SPIII_3

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: C4901_RS11245
• Protein ID: WP_110137404.1
• Coordinates: 2238132..2238425 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: C4901_RS11250
• Protein ID: WP_110137405.1
• Coordinates: 2238415..2238660 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4901_RS11205	2233171..2234691	+	1521	Protein_2203	IS3 family transposase	-
C4901_RS11210	2234838..2235056	-	219	WP_110137401.1	hypothetical protein	-
C4901_RS18115	2235244..2235417	-	174	WP_205735962.1	hypothetical protein	-
C4901_RS18120	2235502..2235945	-	444	WP_205735963.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
C4901_RS11225	2236027..2236467	-	441	WP_168185694.1	type II toxin-antitoxin system PemK/MazF family toxin	-
C4901_RS11235	2236735..2236959	-	225	WP_110137402.1	addiction module protein	-
C4901_RS11245	2238132..2238425	-	294	WP_110137404.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C4901_RS11250	2238415..2238660	-	246	WP_110137405.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
C4901_RS11255	2239431..2240456	+	1026	WP_110137392.1	site-specific integrase	-
C4901_RS11265	2241512..2242243	+	732	WP_110137408.1	NYN domain-containing protein	-
C4901_RS11270	2242506..2242913	-	408	WP_110137409.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Antitoxin ParD (13-63)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11420.16 Da
• Isoelectric Point: 6.2296

>T99815 WP_110137404.1 NZ_CP027663:c2238425-2238132 [Acidiferrobacter sp. SPIII_3]
MRYKLSEATARDIDEILEQSLVEFGVRQMETYYTLLMRRLELLGGNPAIGSVAEDIRPGYRRFPHESHVIFYTIRTEDVL
VVRILHQRMDAIRNIPE

Nucleotide

• Length: 294 bp

>T99815 NZ_CP027663:c2238425-2238132 [Acidiferrobacter sp. SPIII_3]
TTGAGGTATAAGCTCTCCGAGGCCACAGCCCGCGATATCGACGAGATTTTGGAGCAGTCTCTTGTTGAGTTCGGCGTACG
CCAAATGGAAACTTATTACACATTGCTGATGCGCCGTCTAGAATTGCTCGGCGGTAATCCGGCGATAGGTAGTGTGGCCG
AAGACATCCGGCCCGGTTATCGCCGCTTTCCCCATGAGAGTCATGTCATTTTCTACACGATTCGCACCGAAGATGTTCTT
GTCGTCCGCATCTTGCACCAACGCATGGACGCGATCCGCAATATCCCAGAATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9231.41 Da
• Isoelectric Point: 6.4667

>AT99815 WP_110137405.1 NZ_CP027663:c2238660-2238415 [Acidiferrobacter sp. SPIII_3]
MVTMNVSLPGPMKDWVEDQVKTGHYSNASDYVRGLIRRDQEYQDQREALIKALIDGEKSGVSSRTVEEIWRGVKARHGLE
V

Nucleotide

• Length: 246 bp

>AT99815 NZ_CP027663:c2238660-2238415 [Acidiferrobacter sp. SPIII_3]
ATGGTAACCATGAATGTGTCTCTGCCCGGTCCTATGAAGGACTGGGTGGAAGATCAGGTGAAGACGGGTCATTACAGTAA
CGCGAGCGACTATGTTCGTGGCCTCATTCGTCGCGATCAGGAATATCAGGATCAGCGTGAAGCTTTGATTAAGGCGCTCA
TTGATGGGGAAAAGAGTGGCGTGTCGAGCCGCACGGTCGAGGAGATTTGGCGGGGCGTAAAGGCACGGCACGGTCTTGAG
GTATAA