Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2284267..2284852 Replicon chromosome
Accession NZ_CP027656
Organism Pseudomonas chlororaphis subsp. piscium strain ZJU60

Toxin (Protein)


Gene name PumA Uniprot ID A0A3G7C0N8
Locus tag C6Q18_RS10430 Protein ID WP_025804099.1
Coordinates 2284559..2284852 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A3G7CJP2
Locus tag C6Q18_RS10425 Protein ID WP_025804100.1
Coordinates 2284267..2284557 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6Q18_RS10410 2279592..2282072 + 2481 WP_106699012.1 FtsX-like permease family protein -
C6Q18_RS10415 2282062..2283138 + 1077 WP_106696974.1 iron ABC transporter permease -
C6Q18_RS10420 2283266..2283853 + 588 WP_106696975.1 hypothetical protein -
C6Q18_RS10425 2284267..2284557 - 291 WP_025804100.1 putative addiction module antidote protein Antitoxin
C6Q18_RS10430 2284559..2284852 - 294 WP_025804099.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6Q18_RS10435 2285088..2286482 - 1395 WP_106696976.1 VOC family protein -
C6Q18_RS10440 2286745..2287869 + 1125 WP_106696977.1 diguanylate cyclase -
C6Q18_RS10445 2287963..2289207 + 1245 WP_025804096.1 M20/M25/M40 family metallo-hydrolase -
C6Q18_RS10450 2289408..2289806 + 399 WP_025804095.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(9-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10837.49 Da        Isoelectric Point: 10.7289

>T99801 WP_025804099.1 NZ_CP027656:c2284852-2284559 [Pseudomonas chlororaphis subsp. piscium]
MEYEILQTTVFAQWHTRLRDLRARIAIARRIERASAGNLGDVKNLGGGLSEMRVNRGAGYRIYFTVRGNTLIVLLLGGDK
STQPADICQARSLAKEF

Download         Length: 294 bp

>T99801 NZ_CP027656:c2284852-2284559 [Pseudomonas chlororaphis subsp. piscium]
ATGGAATACGAGATCCTGCAGACGACCGTCTTTGCCCAATGGCACACCAGACTACGGGACCTGCGCGCCAGGATAGCCAT
CGCTCGGCGTATCGAGCGGGCTTCGGCGGGCAACCTGGGCGATGTGAAAAACCTCGGCGGCGGTCTCTCGGAAATGCGCG
TGAATAGGGGCGCCGGCTACCGCATCTATTTCACGGTTCGCGGCAACACCCTCATCGTCCTGCTGCTGGGCGGCGACAAG
TCCACCCAGCCTGCCGATATCTGCCAGGCCCGTTCCCTGGCCAAGGAGTTCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10249.81 Da        Isoelectric Point: 8.0096

>AT99801 WP_025804100.1 NZ_CP027656:c2284557-2284267 [Pseudomonas chlororaphis subsp. piscium]
MSDTLVPFDIATLLDSDQAISEYLSQVLADGDTDELIRALGHVARARGMTQIAKATGQGRASLYKAFAPGAKPRFDTVVK
VMRALGLQLCTTVPRG

Download         Length: 291 bp

>AT99801 NZ_CP027656:c2284557-2284267 [Pseudomonas chlororaphis subsp. piscium]
ATGTCCGACACACTGGTTCCCTTCGACATCGCCACCCTGCTCGACAGCGACCAGGCGATCAGCGAATACCTGTCCCAGGT
CCTGGCCGATGGCGATACCGATGAACTGATCCGCGCGCTGGGCCATGTCGCCAGGGCCCGGGGCATGACGCAGATTGCCA
AGGCCACCGGCCAGGGCCGGGCCAGCCTCTACAAGGCCTTTGCCCCGGGCGCCAAGCCGCGCTTCGATACCGTGGTCAAG
GTCATGCGCGCGCTGGGCCTGCAGTTGTGCACCACAGTGCCCCGAGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G7C0N8

Antitoxin

Source ID Structure
AlphaFold DB A0A3G7CJP2

References