Detailed information of TA system TA099799

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 313049..313719
• Replicon: chromosome
• Accession: NZ_CP027656
• Organism: Pseudomonas chlororaphis subsp. piscium strain ZJU60

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: C6Q18_RS01335
• Protein ID: WP_106696247.1
• Coordinates: 313049..313477 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A3G7DZE9
• Locus tag: C6Q18_RS01340
• Protein ID: WP_009046453.1
• Coordinates: 313474..313719 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6Q18_RS01305	308249..308737	-	489	WP_106696243.1	DoxX family protein	-
C6Q18_RS01310	308794..309534	-	741	WP_106696244.1	SDR family oxidoreductase	-
C6Q18_RS01315	309664..310554	+	891	WP_106696245.1	LysR family transcriptional regulator	-
C6Q18_RS01320	310679..310861	+	183	WP_009041685.1	type II toxin-antitoxin system HicA family toxin	-
C6Q18_RS01325	310891..311292	+	402	WP_106698981.1	type II toxin-antitoxin system HicB family antitoxin	-
C6Q18_RS30905	311436..311798	+	363	WP_158703139.1	hypothetical protein	-
C6Q18_RS01330	311882..312919	+	1038	WP_106696246.1	L-glyceraldehyde 3-phosphate reductase	-
C6Q18_RS01335	313049..313477	-	429	WP_106696247.1	type II toxin-antitoxin system VapC family toxin	Toxin
C6Q18_RS01340	313474..313719	-	246	WP_009046453.1	plasmid stabilization protein	Antitoxin
C6Q18_RS01345	313859..314698	-	840	WP_106696248.1	taurine dioxygenase	-
C6Q18_RS01350	314936..315775	-	840	WP_102676416.1	taurine ABC transporter permease TauC	-
C6Q18_RS01355	315772..316566	-	795	WP_106696249.1	taurine ABC transporter ATP-binding subunit	-
C6Q18_RS01360	316676..317653	-	978	WP_106696250.1	taurine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15953.48 Da
• Isoelectric Point: 5.1443

>T99799 WP_106696247.1 NZ_CP027656:c313477-313049 [Pseudomonas chlororaphis subsp. piscium]
MIVLDTNVLSELMRPQPDTAVLLWIEAQPVEDLYISAMTMAEILHGIARLPHGKRKQTLHASALAMFEEDFIDRIVPFET
QAALYYAHLVSHRERSGQPINLVDAQIAAICRVHDAAIATRNTKDFTDTGLIVINPWLPLEI

Nucleotide

• Length: 429 bp

>T99799 NZ_CP027656:c313477-313049 [Pseudomonas chlororaphis subsp. piscium]
ATGATAGTACTCGACACAAATGTGTTGTCAGAACTGATGCGCCCTCAACCGGATACGGCGGTATTGCTGTGGATCGAAGC
GCAACCCGTCGAGGACCTCTACATCAGCGCTATGACCATGGCCGAGATTCTCCACGGCATCGCGCGCCTGCCCCACGGCA
AGCGCAAACAGACGCTGCATGCATCGGCGCTGGCCATGTTCGAGGAAGACTTCATCGACCGGATCGTGCCCTTCGAAACC
CAGGCGGCTCTTTACTACGCGCATCTGGTCTCGCATCGCGAAAGATCAGGCCAGCCGATCAACCTGGTGGACGCGCAGAT
TGCAGCGATATGCCGGGTCCATGACGCCGCGATTGCCACCCGCAACACCAAGGATTTCACCGACACTGGGCTGATCGTTA
TCAACCCCTGGCTACCGCTGGAAATCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9103.27 Da
• Isoelectric Point: 6.2314

>AT99799 WP_009046453.1 NZ_CP027656:c313719-313474 [Pseudomonas chlororaphis subsp. piscium]
MASLTIRNLDDHIKERLRIEAAHNGHSMEEEARLILRRALSRTADSQGLGSRIRARFAETGGVELELPERTEPARLVDLG
E

Nucleotide

• Length: 246 bp

>AT99799 NZ_CP027656:c313719-313474 [Pseudomonas chlororaphis subsp. piscium]
ATGGCCAGCCTTACGATCCGCAATCTGGACGACCACATCAAAGAACGCCTGCGCATCGAGGCCGCTCACAATGGTCATTC
CATGGAAGAAGAAGCCCGATTGATTTTGCGCCGCGCATTGAGCAGGACAGCTGACAGCCAAGGCCTGGGCAGCCGTATCA
GGGCACGCTTTGCCGAGACCGGCGGAGTAGAGTTGGAGCTGCCTGAACGTACCGAACCGGCACGCTTGGTGGACCTGGGC
GAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3G7DZE9