Detailed information of TA system TA099798

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 310679..311292
• Replicon: chromosome
• Accession: NZ_CP027656
• Organism: Pseudomonas chlororaphis subsp. piscium strain ZJU60

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A285EYZ4
• Locus tag: C6Q18_RS01320
• Protein ID: WP_009041685.1
• Coordinates: 310679..310861 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C6Q18_RS01325
• Protein ID: WP_106698981.1
• Coordinates: 310891..311292 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6Q18_RS01295	305865..307829	+	1965	WP_164486059.1	choline transporter BetT	-
C6Q18_RS01300	307939..308196	-	258	WP_063427780.1	hypothetical protein	-
C6Q18_RS01305	308249..308737	-	489	WP_106696243.1	DoxX family protein	-
C6Q18_RS01310	308794..309534	-	741	WP_106696244.1	SDR family oxidoreductase	-
C6Q18_RS01315	309664..310554	+	891	WP_106696245.1	LysR family transcriptional regulator	-
C6Q18_RS01320	310679..310861	+	183	WP_009041685.1	type II toxin-antitoxin system HicA family toxin	Toxin
C6Q18_RS01325	310891..311292	+	402	WP_106698981.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C6Q18_RS30905	311436..311798	+	363	WP_158703139.1	hypothetical protein	-
C6Q18_RS01330	311882..312919	+	1038	WP_106696246.1	L-glyceraldehyde 3-phosphate reductase	-
C6Q18_RS01335	313049..313477	-	429	WP_106696247.1	type II toxin-antitoxin system VapC family toxin	-
C6Q18_RS01340	313474..313719	-	246	WP_009046453.1	plasmid stabilization protein	-
C6Q18_RS01345	313859..314698	-	840	WP_106696248.1	taurine dioxygenase	-
C6Q18_RS01350	314936..315775	-	840	WP_102676416.1	taurine ABC transporter permease TauC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6933.08 Da
• Isoelectric Point: 10.4588

>T99798 WP_009041685.1 NZ_CP027656:310679-310861 [Pseudomonas chlororaphis subsp. piscium]
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Nucleotide

• Length: 183 bp

>T99798 NZ_CP027656:310679-310861 [Pseudomonas chlororaphis subsp. piscium]
ATGCGCAGTCGGGAACTGATCAGGATGATCGAGGAGGACGGGTGGTATCTGATCGCGGTCAAAGGCAGTCATCACCAGTA
CAAGCATCTGCACAAGCCGGGGCGGGTCACTATCCCTCACCCGGATGCGGATCTGCCCAGGGGCACGATCCACAGCATCT
TGAAACAGGCGGGCCTGAAATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14596.40 Da
• Isoelectric Point: 4.9036

>AT99798 WP_106698981.1 NZ_CP027656:310891-311292 [Pseudomonas chlororaphis subsp. piscium]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAQAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGVV
DFDITPYFGRAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Nucleotide

• Length: 402 bp

>AT99798 NZ_CP027656:310891-311292 [Pseudomonas chlororaphis subsp. piscium]
ATGAAATTCCCGGTCGTGCTGCACAAGGATGCCGACTCCGGATATGGAGTGATCGTCCCCGATGTGCCGGGCTGTTTTTC
CGCCGGTCATACCGCTGCGCAAGCCTTCGAGAATGTGAAAGAAGCCTTGTCGCTGCACTACGAAGGCCTGGTCGCCGATG
GTGAGCCGCTGCCCCAGGTACATGAGGTTGATGTGCATATCGACAATCCCGATTACGCCGGCGGTGTATGGGGGGTGGTC
GATTTCGATATCACGCCTTACTTCGGCAGGGCGGTGCGCTTCAATGCCACCCTGCCGGAGCAACTGTTGGAGCGCATCGA
CCAAACGGTGAAGCGCGACCAGCGCTACCGTTCACGCTCGGGTTTTCTCGCGGCAGCGGCACTACGCGAGCTCTCCGCCT
AG

Structures

Toxin

• AlphaFold DB: A0A285EYZ4