Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel2-ATphRel2/DUF4065(antitoxin)
Location 171524..172961 Replicon plasmid pIBB3154_1
Accession NZ_CP027645
Organism Ligilactobacillus salivarius strain IBB3154

Toxin (Protein)


Gene name phRel2 Uniprot ID -
Locus tag IBB3154_RS10380 Protein ID WP_164480353.1
Coordinates 172281..172961 (-) Length 227 a.a.

Antitoxin (Protein)


Gene name ATphRel2 Uniprot ID -
Locus tag IBB3154_RS10375 Protein ID WP_164480352.1
Coordinates 171524..172276 (-) Length 251 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBB3154_RS10355 (IBB3154_162) 167316..167813 + 498 WP_164480349.1 helix-turn-helix transcriptional regulator -
IBB3154_RS10360 167888..168304 + 417 WP_164480350.1 helix-turn-helix transcriptional regulator -
IBB3154_RS10365 (IBB3154_163) 168964..169734 - 771 WP_164480351.1 Fic family protein -
IBB3154_RS10370 (IBB3154_164) 170086..171375 - 1290 WP_003708871.1 ISL3 family transposase -
IBB3154_RS10375 (IBB3154_165) 171524..172276 - 753 WP_164480352.1 DUF4065 domain-containing protein Antitoxin
IBB3154_RS10380 (IBB3154_166) 172281..172961 - 681 WP_164480353.1 hypothetical protein Toxin
IBB3154_RS10385 (IBB3154_167) 173329..174555 + 1227 WP_164480354.1 ParM/StbA family protein -
IBB3154_RS10390 (IBB3154_168) 174575..174964 + 390 WP_003699492.1 hypothetical protein -
IBB3154_RS10395 (IBB3154_169) 175561..175863 + 303 WP_003699490.1 hypothetical protein -
IBB3154_RS10400 (IBB3154_170) 176121..176999 + 879 WP_003708476.1 patatin family protein -
IBB3154_RS10405 (IBB3154_171) 177085..177921 - 837 WP_081531053.1 pyruvate formate-lyase-activating protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..230637 230637


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(112-224)


Sequences

Toxin        


Download         Length: 227 a.a.        Molecular weight: 27352.87 Da        Isoelectric Point: 6.1689

>T99797 WP_164480353.1 NZ_CP027645:c172961-172281 [Ligilactobacillus salivarius]
MNNEENMLIDIVKIINYIGDLHKGFSEEFFSNHDSFNLKRTTVAKVIKDESTYDVDFINLVDSYIEEITIFQLTHDFEIN
NDKIDPRFRGKTRESALNKLYYYSVRPVGADFPLQKCLNDLLGFRIIIDNIFDYNDLLTDIKKSPYLKTKISRSYIRRDI
DEDRDIKYIGIHIYFKSENNKFFPWELQIWQKDDAILNEKSHRKHKQKRRYINWAEEYKDNRHEEE

Download         Length: 681 bp

>T99797 NZ_CP027645:c172961-172281 [Ligilactobacillus salivarius]
TTGAATAATGAAGAGAATATGCTTATCGATATCGTGAAAATTATTAATTATATTGGTGATTTACACAAAGGATTTTCTGA
AGAATTCTTTTCAAACCATGATTCTTTTAATCTTAAAAGGACAACTGTAGCAAAAGTGATTAAAGATGAATCAACGTATG
ACGTAGATTTTATTAATCTTGTAGACAGTTATATTGAAGAAATTACAATATTTCAATTGACCCATGATTTTGAAATAAAT
AATGATAAAATTGATCCTAGATTTAGAGGTAAGACTAGGGAATCTGCTTTAAATAAATTATATTATTATAGCGTTAGACC
TGTAGGAGCCGATTTTCCTTTACAAAAATGTTTGAATGATTTATTAGGTTTTAGAATAATTATCGATAATATTTTTGATT
ATAATGATCTATTAACGGATATAAAGAAGTCACCTTATTTAAAGACTAAGATTTCAAGAAGTTACATTCGTAGAGATATA
GATGAAGATAGGGATATAAAGTATATCGGCATTCATATTTATTTTAAAAGTGAAAATAATAAATTTTTTCCGTGGGAACT
ACAAATTTGGCAAAAAGATGATGCAATACTAAATGAAAAGTCCCATAGAAAACACAAACAAAAAAGAAGATACATTAATT
GGGCAGAAGAATACAAAGATAATCGGCATGAGGAGGAATGA

Antitoxin


Download         Length: 251 a.a.        Molecular weight: 28751.97 Da        Isoelectric Point: 6.8542

>AT99797 WP_164480352.1 NZ_CP027645:c172276-171524 [Ligilactobacillus salivarius]
MIQHIIAISTSYVLGTRIAWHYADNKISPSVLEELSKKTKSILGSPEYSIHKLNTDSKSWSSVIEKDSFFKDLTVFESID
DFLNAINSDKQVTALDIAKLLLSIQPMTHLKLQKMIYLAYADYLSLTKKRLFEDEILAFKYGPVVREVYDYYKANGSQTI
EGQIDDRKYIHLNDITIPMTLAKILQSDDKKDILNSVKETFARYGSKTAYELVDITHREGSPWDRAEKLGRNTRITDDLI
LKYHSVELVM

Download         Length: 753 bp

>AT99797 NZ_CP027645:c172276-171524 [Ligilactobacillus salivarius]
ATGATACAACATATTATTGCAATTAGTACATCGTATGTTCTTGGAACAAGAATAGCCTGGCACTATGCAGACAATAAAAT
TTCTCCTAGTGTATTAGAAGAATTATCTAAAAAAACAAAGTCTATATTAGGTAGTCCTGAATACTCAATTCACAAATTAA
ATACTGATTCTAAGAGTTGGAGTAGTGTTATTGAAAAAGATAGTTTCTTTAAGGATCTTACAGTTTTTGAAAGCATAGAT
GATTTTTTAAATGCAATTAATTCTGATAAGCAAGTGACTGCTTTAGATATTGCTAAATTATTATTATCAATTCAGCCAAT
GACACATTTGAAATTGCAAAAAATGATATATTTGGCTTATGCTGATTACTTATCTTTAACAAAGAAAAGGCTATTTGAAG
ATGAAATTTTAGCATTTAAATATGGGCCAGTTGTTAGAGAAGTTTACGACTACTATAAAGCTAATGGTAGTCAAACTATT
GAAGGACAAATTGATGATAGAAAATATATACATTTAAACGATATTACGATACCGATGACTTTAGCGAAGATACTACAGTC
TGATGACAAGAAAGATATTTTAAATTCAGTTAAGGAAACATTTGCAAGGTATGGTTCTAAAACAGCATATGAATTAGTTG
ATATTACTCATAGAGAGGGGAGTCCTTGGGATAGGGCAGAGAAACTTGGGAGAAATACAAGAATAACAGATGATTTAATA
TTAAAGTATCATAGCGTAGAATTAGTCATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References