Detailed information of TA system TA099796

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 987677..988161
• Replicon: chromosome
• Accession: NZ_CP027644
• Organism: Ligilactobacillus salivarius strain IBB3154

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: IBB3154_RS05015
• Protein ID: WP_081534446.1
• Coordinates: 987904..988161 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: IBB3154_RS05010
• Protein ID: WP_081534449.1
• Coordinates: 987677..987904 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IBB3154_RS04980 (IBB3154_0982)	982942..983229	-	288	WP_081534479.1	hypothetical protein	-
IBB3154_RS04985 (IBB3154_0983)	983243..985192	-	1950	WP_081534477.1	virulence factor	-
IBB3154_RS04990 (IBB3154_0984)	985207..985845	-	639	WP_081534474.1	hypothetical protein	-
IBB3154_RS04995 (IBB3154_0985)	985857..986147	-	291	WP_081534472.1	hypothetical protein	-
IBB3154_RS05000 (IBB3154_0986)	986664..986975	-	312	WP_087366498.1	hypothetical protein	-
IBB3154_RS05005 (IBB3154_0987)	986989..987330	-	342	WP_164479981.1	hypothetical protein	-
IBB3154_RS05010 (IBB3154_0988)	987677..987904	-	228	WP_081534449.1	hypothetical protein	Antitoxin
IBB3154_RS05015 (IBB3154_0989)	987904..988161	-	258	WP_081534446.1	type II toxin-antitoxin system HicA family toxin	Toxin
IBB3154_RS05020 (IBB3154_0990)	988206..988376	-	171	WP_158227664.1	hypothetical protein	-
IBB3154_RS05025 (IBB3154_0991)	988379..988648	-	270	WP_081534443.1	hypothetical protein	-
IBB3154_RS05030 (IBB3154_0992)	989066..989344	-	279	WP_213075584.1	hypothetical protein	-
IBB3154_RS05035 (IBB3154_0993)	989367..989702	-	336	WP_087366483.1	hypothetical protein	-
IBB3154_RS05040 (IBB3154_0994)	989715..990068	-	354	WP_087366480.1	hypothetical protein	-
IBB3154_RS05045 (IBB3154_0995)	990367..991074	-	708	WP_087366477.1	hypothetical protein	-
IBB3154_RS05050	991105..991413	-	309	WP_249742313.1	hypothetical protein	-
IBB3154_RS05055 (IBB3154_0997)	991403..991744	-	342	WP_087366475.1	hypothetical protein	-
IBB3154_RS05060 (IBB3154_0998)	992263..992535	+	273	WP_081534404.1	HU family DNA-binding protein	-
IBB3154_RS05065 (IBB3154_0999)	992627..992944	-	318	WP_087366472.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (21-76)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9821.66 Da
• Isoelectric Point: 10.3028

>T99796 WP_081534446.1 NZ_CP027644:c988161-987904 [Ligilactobacillus salivarius]
MGKKDKLLAKLLSKPKDFTFNELETLLEYLGFYLDNVGKTSGSRVRFVNDELRIVIKLHKPHHQKVLLPYQIKEVISKLE
KGGII

Nucleotide

• Length: 258 bp

>T99796 NZ_CP027644:c988161-987904 [Ligilactobacillus salivarius]
TTGGGTAAAAAAGATAAGTTACTAGCTAAATTATTGAGTAAACCTAAAGATTTTACATTTAATGAGTTAGAAACATTACT
TGAGTATTTAGGTTTTTATCTTGATAATGTTGGTAAAACAAGTGGCTCAAGGGTTAGATTTGTAAATGATGAATTAAGGA
TAGTTATAAAACTACATAAGCCACATCATCAAAAAGTATTGTTACCTTATCAAATAAAAGAAGTCATCTCAAAATTAGAA
AAAGGTGGGATAATCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8860.08 Da
• Isoelectric Point: 4.3575

>AT99796 WP_081534449.1 NZ_CP027644:c987904-987677 [Ligilactobacillus salivarius]
MNKLLRYKDYLGTVEYSLNDKVFFGEVLGIKSLLSYQGNTIEELEEDFKETVEDYLELCNRKKWDPEKTSMVVVN

Nucleotide

• Length: 228 bp

>AT99796 NZ_CP027644:c987904-987677 [Ligilactobacillus salivarius]
ATGAATAAATTATTAAGATACAAAGATTATTTAGGTACGGTGGAATATTCGTTAAATGATAAAGTCTTTTTTGGTGAAGT
TTTGGGAATCAAAAGCTTATTATCTTATCAAGGTAATACAATTGAAGAACTGGAAGAAGATTTTAAAGAAACTGTAGAAG
ATTATTTAGAGCTTTGCAATCGTAAAAAATGGGATCCAGAAAAAACCAGTATGGTTGTTGTTAATTAA