Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 773889..774546 Replicon chromosome
Accession NZ_CP027618
Organism Enterobacter cloacae complex sp. FDA-CDC-AR_0132

Toxin (Protein)


Gene name cptA Uniprot ID G8LDB6
Locus tag AM379_RS03670 Protein ID WP_014171514.1
Coordinates 773889..774299 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag AM379_RS03675 Protein ID WP_003863437.1
Coordinates 774280..774546 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM379_RS03650 769887..771620 - 1734 WP_032678922.1 single-stranded-DNA-specific exonuclease RecJ -
AM379_RS03655 771626..772339 - 714 WP_020883731.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM379_RS03660 772363..773259 - 897 WP_032678923.1 site-specific tyrosine recombinase XerD -
AM379_RS03665 773361..773882 + 522 WP_014171513.1 flavodoxin FldB -
AM379_RS03670 773889..774299 - 411 WP_014171514.1 protein YgfX Toxin
AM379_RS03675 774280..774546 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
AM379_RS03680 774841..775821 + 981 WP_032678924.1 tRNA-modifying protein YgfZ -
AM379_RS03685 775932..776591 - 660 WP_014171517.1 hemolysin III family protein -
AM379_RS03690 776858..777589 + 732 WP_020883729.1 MurR/RpiR family transcriptional regulator -
AM379_RS03695 777706..779139 + 1434 WP_032678925.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16217.15 Da        Isoelectric Point: 11.5020

>T99784 WP_014171514.1 NZ_CP027618:c774299-773889 [Enterobacter cloacae complex sp. FDA-CDC-AR_0132]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRIHARQGEIKLLMDSRLRWQGK
EWEILGMPWMIASGMMLRLRSVDSGRRQHLWLAADSMDSAEWRDLRRMLLQQLTQE

Download         Length: 411 bp

>T99784 NZ_CP027618:c774299-773889 [Enterobacter cloacae complex sp. FDA-CDC-AR_0132]
GTGGTCCTGTGGCAATCTGACCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTGTTGCTCCACGGCCTGGTCGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTTAGCTATACGCCTCTGTGGCTGCTGTTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGCCGCATTCATGCCCGTCAGGGGGAGATCAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATTCTCGGTATGCCCTGGATGATCGCTTCCGGCATGATGCTGCGGCTACGTAGCGTGGACAGCGGGCGTCG
CCAGCATCTGTGGCTGGCTGCGGACAGTATGGATAGCGCTGAGTGGCGGGACCTGCGTCGGATGTTATTACAGCAGCTGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT99784 WP_003863437.1 NZ_CP027618:c774546-774280 [Enterobacter cloacae complex sp. FDA-CDC-AR_0132]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT99784 NZ_CP027618:c774546-774280 [Enterobacter cloacae complex sp. FDA-CDC-AR_0132]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCTGATT
TATTTAACTGGCTGATGAATCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BUV6

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References