Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2729415..2729931 Replicon chromosome
Accession NZ_CP027612
Organism Klebsiella pneumoniae subsp. ozaenae strain AR_0096

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag AM475_RS13750 Protein ID WP_004192395.1
Coordinates 2729647..2729931 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag AM475_RS13745 Protein ID WP_004192397.1
Coordinates 2729415..2729657 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM475_RS13730 2725443..2726183 + 741 WP_002886899.1 KDGP aldolase family protein -
AM475_RS13735 2726250..2727404 + 1155 WP_004178372.1 lactonase family protein -
AM475_RS13740 2727427..2729337 + 1911 WP_004152270.1 BglG family transcription antiterminator -
AM475_RS13745 2729415..2729657 + 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AM475_RS13750 2729647..2729931 + 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM475_RS13755 2729935..2730399 - 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AM475_RS13760 2730707..2732845 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
AM475_RS13765 2733202..2733945 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
AM475_RS29920 2733948..2734121 - 174 WP_002886906.1 hypothetical protein -
AM475_RS13770 2734206..2734514 + 309 WP_004192389.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T99778 WP_004192395.1 NZ_CP027612:2729647-2729931 [Klebsiella pneumoniae subsp. ozaenae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

>T99778 NZ_CP027612:2729647-2729931 [Klebsiella pneumoniae subsp. ozaenae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGTGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT99778 WP_004192397.1 NZ_CP027612:2729415-2729657 [Klebsiella pneumoniae subsp. ozaenae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT99778 NZ_CP027612:2729415-2729657 [Klebsiella pneumoniae subsp. ozaenae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGTGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References