Detailed information of TA system TA099761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2492331..2493010
• Replicon: chromosome
• Accession: NZ_CP027607
• Organism: Acinetobacter baumannii strain AR_0102

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: AM481_RS12010
• Protein ID: WP_000838146.1
• Coordinates: 2492331..2492513 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: AM481_RS12015
• Protein ID: WP_000966688.1
• Coordinates: 2492606..2493010 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM481_RS11965	2487404..2487808	+	405	WP_000247948.1	hypothetical protein	-
AM481_RS11970	2487780..2488148	+	369	WP_002055488.1	hypothetical protein	-
AM481_RS11975	2488150..2488548	+	399	WP_001251850.1	hypothetical protein	-
AM481_RS11980	2488550..2488768	+	219	WP_001277687.1	hypothetical protein	-
AM481_RS11985	2488862..2489215	+	354	WP_000064599.1	hypothetical protein	-
AM481_RS11990	2489215..2490450	+	1236	WP_000002422.1	hypothetical protein	-
AM481_RS11995	2490503..2491420	+	918	WP_000094250.1	hypothetical protein	-
AM481_RS12000	2491490..2492005	+	516	WP_001185608.1	hypothetical protein	-
AM481_RS12010	2492331..2492513	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
AM481_RS12015	2492606..2493010	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AM481_RS12020	2493109..2493285	+	177	WP_014466185.1	hypothetical protein	-
AM481_RS12025	2493294..2493617	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
AM481_RS12030	2493649..2494443	+	795	WP_000720608.1	hypothetical protein	-
AM481_RS12035	2494492..2494731	-	240	WP_000763623.1	Arc family DNA-binding protein	-
AM481_RS12040	2494854..2495009	+	156	WP_001103649.1	Arc family DNA-binding protein	-
AM481_RS12045	2495006..2495998	+	993	WP_000835645.1	KilA-N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2454222..2516297	62075

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T99761 WP_000838146.1 NZ_CP027607:2492331-2492513 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T99761 NZ_CP027607:2492331-2492513 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT99761 WP_000966688.1 NZ_CP027607:2492606-2493010 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT99761 NZ_CP027607:2492606-2493010 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6