Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
| Location | 1496757..1497460 | Replicon | chromosome |
| Accession | NZ_CP027604 | ||
| Organism | Enterobacter cloacae complex sp. strain AR_0093 | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | A0A8B5ZZ18 |
| Locus tag | AM472_RS07310 | Protein ID | WP_039268718.1 |
| Coordinates | 1497119..1497460 (+) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | A0A8B5ZWQ9 |
| Locus tag | AM472_RS07305 | Protein ID | WP_039268717.1 |
| Coordinates | 1496757..1497098 (+) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AM472_RS07270 (AM472_07265) | 1491910..1492785 | + | 876 | WP_039268712.1 | GTPase family protein | - |
| AM472_RS07275 (AM472_07270) | 1493029..1493745 | + | 717 | WP_039268713.1 | WYL domain-containing protein | - |
| AM472_RS07280 (AM472_07275) | 1493781..1494233 | + | 453 | WP_039269148.1 | hypothetical protein | - |
| AM472_RS07285 (AM472_07280) | 1494305..1494778 | + | 474 | WP_039268714.1 | hypothetical protein | - |
| AM472_RS07290 (AM472_07285) | 1494899..1495720 | + | 822 | WP_039268715.1 | DUF932 domain-containing protein | - |
| AM472_RS07295 (AM472_07290) | 1495751..1496191 | + | 441 | WP_039268716.1 | antirestriction protein | - |
| AM472_RS07300 (AM472_07295) | 1496204..1496746 | + | 543 | WP_045259572.1 | DNA repair protein RadC | - |
| AM472_RS07305 (AM472_07300) | 1496757..1497098 | + | 342 | WP_039268717.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| AM472_RS07310 (AM472_07305) | 1497119..1497460 | + | 342 | WP_039268718.1 | TA system toxin CbtA family protein | Toxin |
| AM472_RS07315 (AM472_07310) | 1497715..1498722 | + | 1008 | WP_039268719.1 | restriction endonuclease | - |
| AM472_RS07325 (AM472_07320) | 1498903..1499739 | - | 837 | Protein_1371 | HNH endonuclease | - |
| AM472_RS07330 (AM472_07325) | 1500039..1500506 | + | 468 | WP_022650322.1 | SymE family type I addiction module toxin | - |
| AM472_RS07335 (AM472_07330) | 1500564..1500935 | - | 372 | WP_022650323.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | fosA | - | 1450201..1505406 | 55205 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12772.83 Da Isoelectric Point: 9.6548
>T99744 WP_039268718.1 NZ_CP027604:1497119-1497460 [Enterobacter cloacae complex sp.]
MKTLPATTPQAAKLCLLPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR
MKTLPATTPQAAKLCLLPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR
Download Length: 342 bp
>T99744 NZ_CP027604:1497119-1497460 [Enterobacter cloacae complex sp.]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGAAGCTATGTCTGTTGCCCGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACGCCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCTTATCTGCGGGCGGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGAAGCTATGTCTGTTGCCCGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACGCCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCTTATCTGCGGGCGGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA
Antitoxin
Download Length: 114 a.a. Molecular weight: 12729.40 Da Isoelectric Point: 6.9460
>AT99744 WP_039268717.1 NZ_CP027604:1496757-1497098 [Enterobacter cloacae complex sp.]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRVSITGKFSEAECLKLDVAFPHFISQMESMLTTGGMNPRH
AHCVTLYHNGFTCEADTLGSYGYVYIAVYPTQR
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRVSITGKFSEAECLKLDVAFPHFISQMESMLTTGGMNPRH
AHCVTLYHNGFTCEADTLGSYGYVYIAVYPTQR
Download Length: 342 bp
>AT99744 NZ_CP027604:1496757-1497098 [Enterobacter cloacae complex sp.]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCTAGCTGACCGGGTCAGTATCACCGGTAAGTTCAGCGAAGCAGAATGTC
TTAAGCTGGATGTGGCATTCCCACATTTTATCAGCCAGATGGAGTCGATGTTGACTACTGGTGGAATGAATCCTCGCCAT
GCCCACTGTGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCTAGCTGACCGGGTCAGTATCACCGGTAAGTTCAGCGAAGCAGAATGTC
TTAAGCTGGATGTGGCATTCCCACATTTTATCAGCCAGATGGAGTCGATGTTGACTACTGGTGGAATGAATCCTCGCCAT
GCCCACTGTGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A8B5ZZ18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A8B5ZWQ9 |