Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3894129..3894607 Replicon chromosome
Accession NZ_CP027599
Organism Escherichia coli strain 97-3250

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag C7A06_RS21910 Protein ID WP_001303876.1
Coordinates 3894320..3894607 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag C7A06_RS21905 Protein ID WP_000536233.1
Coordinates 3894129..3894320 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7A06_RS21870 3889511..3890281 - 771 WP_032324560.1 DUF1627 domain-containing protein -
C7A06_RS21875 3890307..3891047 - 741 WP_021498074.1 ATP-binding protein -
C7A06_RS21880 3891054..3892169 - 1116 WP_001205820.1 hypothetical protein -
C7A06_RS21885 3892248..3892703 + 456 WP_000273724.1 hypothetical protein -
C7A06_RS21890 3892910..3893335 - 426 WP_000693855.1 Rha family transcriptional regulator -
C7A06_RS21895 3893319..3893591 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
C7A06_RS21900 3893700..3894101 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
C7A06_RS21905 3894129..3894320 + 192 WP_000536233.1 hypothetical protein Antitoxin
C7A06_RS21910 3894320..3894607 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C7A06_RS21915 3894884..3895036 + 153 WP_000379552.1 DUF1391 family protein -
C7A06_RS21920 3895048..3895686 + 639 WP_000394543.1 hypothetical protein -
C7A06_RS21925 3895687..3895896 - 210 WP_001133037.1 hypothetical protein -
C7A06_RS21935 3896464..3896652 + 189 WP_000413705.1 cell division inhibition protein DicB -
C7A06_RS21940 3896649..3896840 + 192 WP_001098307.1 DUF1482 family protein -
C7A06_RS21945 3896934..3899384 + 2451 WP_009448824.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T99733 WP_001303876.1 NZ_CP027599:3894320-3894607 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T99733 NZ_CP027599:3894320-3894607 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT99733 WP_000536233.1 NZ_CP027599:3894129-3894320 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT99733 NZ_CP027599:3894129-3894320 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References