Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 3281303..3281829 | Replicon | chromosome |
| Accession | NZ_CP027599 | ||
| Organism | Escherichia coli strain 97-3250 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | C7A06_RS17875 | Protein ID | WP_000323025.1 |
| Coordinates | 3281303..3281590 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | C7A06_RS17880 | Protein ID | WP_000534858.1 |
| Coordinates | 3281590..3281829 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C7A06_RS17835 | 3276327..3276542 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| C7A06_RS34750 | 3276762..3276932 | + | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| C7A06_RS17840 | 3277296..3277511 | - | 216 | WP_000066483.1 | cold shock-like protein CspB | - |
| C7A06_RS17845 | 3277812..3278024 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| C7A06_RS34155 | 3278079..3278168 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| C7A06_RS17850 | 3278446..3279198 | - | 753 | WP_001047133.1 | antitermination protein | - |
| C7A06_RS17855 | 3279212..3280261 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| C7A06_RS17860 | 3280263..3280541 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| C7A06_RS17865 | 3280608..3280859 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| C7A06_RS17870 | 3281076..3281231 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| C7A06_RS17875 | 3281303..3281590 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| C7A06_RS17880 | 3281590..3281829 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| C7A06_RS17885 | 3281854..3282159 | + | 306 | WP_001326990.1 | hypothetical protein | - |
| C7A06_RS17890 | 3282362..3282694 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| C7A06_RS17895 | 3283131..3284471 | - | 1341 | WP_000589012.1 | ISNCY family transposase | - |
| C7A06_RS17900 | 3285105..3286202 | + | 1098 | WP_000156210.1 | beta family protein | - |
| C7A06_RS17905 | 3286162..3286740 | - | 579 | WP_001204666.1 | sce7726 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | espM2 / espW / espK / paa | 3245977..3428705 | 182728 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T99731 WP_000323025.1 NZ_CP027599:c3281590-3281303 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T99731 NZ_CP027599:c3281590-3281303 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT99731 WP_000534858.1 NZ_CP027599:c3281829-3281590 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT99731 NZ_CP027599:c3281829-3281590 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|