Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2272805..2273640 Replicon chromosome
Accession NZ_CP027599
Organism Escherichia coli strain 97-3250

Toxin (Protein)


Gene name yeeV Uniprot ID A0A136X5A2
Locus tag C7A06_RS12315 Protein ID WP_000854757.1
Coordinates 2272805..2273182 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag C7A06_RS12320 Protein ID WP_001295723.1
Coordinates 2273272..2273640 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7A06_RS12275 2268325..2268798 + 474 WP_001105384.1 DNA gyrase inhibitor SbmC -
C7A06_RS12280 2268996..2270054 + 1059 WP_001200883.1 FUSC family protein -
C7A06_RS12285 2270226..2270555 + 330 WP_000450409.1 DUF496 family protein -
C7A06_RS12290 2270656..2270838 - 183 WP_024167529.1 ethanolamine utilization protein -
C7A06_RS12300 2271292..2272320 - 1029 Protein_2279 IS110 family transposase -
C7A06_RS34500 2272479..2272592 - 114 WP_001161660.1 DUF957 domain-containing protein -
C7A06_RS12310 2272605..2272808 - 204 WP_000761705.1 hypothetical protein -
C7A06_RS12315 2272805..2273182 - 378 WP_000854757.1 TA system toxin CbtA family protein Toxin
C7A06_RS12320 2273272..2273640 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C7A06_RS12325 2273803..2274024 - 222 WP_000692323.1 DUF987 domain-containing protein -
C7A06_RS12330 2274093..2274569 - 477 WP_001186725.1 RadC family protein -
C7A06_RS12335 2274585..2275070 - 486 WP_000849582.1 antirestriction protein -
C7A06_RS12340 2275125..2275943 - 819 WP_001234620.1 DUF945 domain-containing protein -
C7A06_RS12350 2276043..2276276 - 234 WP_001119729.1 DUF905 family protein -
C7A06_RS12355 2276355..2276696 - 342 WP_072097794.1 hypothetical protein -
C7A06_RS12360 2276785..2277189 + 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
C7A06_RS12365 2277186..2277533 + 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14153.18 Da        Isoelectric Point: 7.3249

>T99710 WP_000854757.1 NZ_CP027599:c2273182-2272805 [Escherichia coli]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T99710 NZ_CP027599:c2273182-2272805 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT99710 WP_001295723.1 NZ_CP027599:c2273640-2273272 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT99710 NZ_CP027599:c2273640-2273272 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A136X5A2

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References