Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3178632..3179427 Replicon chromosome
Accession NZ_CP027591
Organism Escherichia coli strain 2014C-3011

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag C7A05_RS18515 Protein ID WP_000854914.1
Coordinates 3178632..3179006 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag C7A05_RS18520 Protein ID WP_001280954.1
Coordinates 3179053..3179427 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7A05_RS18485 3175310..3176014 + 705 WP_062882312.1 leucyl/phenylalanyl-tRNA--protein transferase -
C7A05_RS18490 3176299..3176517 + 219 WP_001040187.1 translation initiation factor IF-1 -
C7A05_RS18500 3177008..3177850 - 843 WP_001280481.1 DUF4942 domain-containing protein -
C7A05_RS18505 3177935..3178132 - 198 WP_000839282.1 DUF957 domain-containing protein -
C7A05_RS18510 3178144..3178635 - 492 WP_000976857.1 hypothetical protein -
C7A05_RS18515 3178632..3179006 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
C7A05_RS18520 3179053..3179427 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C7A05_RS18525 3179590..3179811 - 222 WP_001220314.1 DUF987 domain-containing protein -
C7A05_RS18530 3179874..3180350 - 477 WP_062882313.1 RadC family protein -
C7A05_RS18535 3180366..3180851 - 486 WP_000214398.1 antirestriction protein -
C7A05_RS18540 3180942..3181760 - 819 WP_001234682.1 DUF945 domain-containing protein -
C7A05_RS18555 3182100..3183169 - 1070 Protein_3244 patatin-like phospholipase family protein -
C7A05_RS18560 3183166..3184071 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T99697 WP_000854914.1 NZ_CP027591:c3179006-3178632 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T99697 NZ_CP027591:c3179006-3178632 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT99697 WP_001280954.1 NZ_CP027591:c3179427-3179053 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT99697 NZ_CP027591:c3179427-3179053 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References