Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 842544..843023 Replicon chromosome
Accession NZ_CP027587
Organism Escherichia coli strain 2013C-4974

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag C6998_RS04470 Protein ID WP_000938157.1
Coordinates 842544..842831 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID -
Locus tag C6998_RS04475 Protein ID WP_001300743.1
Coordinates 842832..843023 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6998_RS04435 837666..837908 - 243 WP_000273151.1 DUF4224 domain-containing protein -
C6998_RS04440 837976..840411 - 2436 WP_057711277.1 exonuclease -
C6998_RS04445 840505..840696 - 192 WP_001098307.1 DUF1482 family protein -
C6998_RS04450 840693..840881 - 189 WP_000413705.1 cell division inhibition protein DicB -
C6998_RS04460 841585..842031 + 447 WP_000373334.1 hypothetical protein -
C6998_RS04465 842130..842281 - 152 Protein_806 YdaF family protein -
C6998_RS04470 842544..842831 - 288 WP_000938157.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6998_RS04475 842832..843023 - 192 WP_001300743.1 hypothetical protein Antitoxin
C6998_RS04480 842992..843453 - 462 WP_000538413.1 helix-turn-helix domain-containing protein -
C6998_RS28445 843484..843855 - 372 WP_000448218.1 hypothetical protein -
C6998_RS04490 843958..844239 + 282 WP_021577226.1 helix-turn-helix domain-containing protein -
C6998_RS04495 844243..844668 + 426 WP_000693825.1 Rha family transcriptional regulator -
C6998_RS04500 844875..845330 - 456 WP_000273724.1 hypothetical protein -
C6998_RS04505 845409..846535 + 1127 Protein_814 DNA-binding protein -
C6998_RS04510 846542..847286 + 745 Protein_815 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - nleC 835602..871121 35519


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10967.74 Da        Isoelectric Point: 6.7144

>T99649 WP_000938157.1 NZ_CP027587:c842831-842544 [Escherichia coli]
MLPVLWLESADADLDNITSYIARFDIDAAERLWKRLRTCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTISGIE
IVNVVHARRQFPVTP

Download         Length: 288 bp

>T99649 NZ_CP027587:c842831-842544 [Escherichia coli]
ATGTTACCGGTTTTATGGCTCGAAAGCGCAGATGCCGACCTAGATAATATAACCAGCTATATTGCACGTTTTGACATAGA
TGCGGCAGAACGTTTGTGGAAACGCTTAAGGACTTGCGTCCTGCCATTATCTGAACATCCGTATTTATACCCGCCAAGCG
ACAGAGTGCCTGGTTTGCGTGAAATTGTAGCTCACCCCAATTACATCATTCTGTACCGCGTGACAATTTCAGGCATTGAA
ATTGTTAACGTAGTTCACGCCCGCCGACAGTTCCCTGTAACACCTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7350.26 Da        Isoelectric Point: 5.8256

>AT99649 WP_001300743.1 NZ_CP027587:c843023-842832 [Escherichia coli]
MNTALSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVERRMAERFANMRKERSKQ

Download         Length: 192 bp

>AT99649 NZ_CP027587:c843023-842832 [Escherichia coli]
ATGAACACGGCCCTTTCACCAATGGTTTCTGAATTTGAAACCGTCGAGCAAGAAAATAGTTATAACGAATGGCTGCGTGC
AAAAGTGGCCGCAAGCCTTGCTGATCCACGTCCAGCCATTCCCCATGACGAAGTTGAACGCAGAATGGCTGAACGCTTTG
CTAACATGCGCAAGGAACGGAGCAAACAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References