Detailed information of TA system TA099633

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 2926685..2927280
• Replicon: chromosome
• Accession: NZ_CP027586
• Organism: Escherichia coli strain 2012EL-2448

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: U9Y4M4
• Locus tag: C7A04_RS15640
• Protein ID: WP_000239579.1
• Coordinates: 2926930..2927280 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: -
• Locus tag: C7A04_RS15635
• Protein ID: WP_106913399.1
• Coordinates: 2926685..2926936 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7A04_RS15625	2922350..2926129	+	3780	WP_000060887.1	autotransporter assembly complex protein TamB	-
C7A04_RS15630	2926132..2926473	+	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
C7A04_RS15635	2926685..2926936	+	252	WP_106913399.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
C7A04_RS15640	2926930..2927280	+	351	WP_000239579.1	endoribonuclease toxin ChpB	Toxin
C7A04_RS15645	2927360..2927890	-	531	WP_000055075.1	inorganic diphosphatase	-
C7A04_RS15650	2928200..2929156	+	957	WP_000265933.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
C7A04_RS15655	2929296..2930798	+	1503	WP_000210554.1	sugar ABC transporter ATP-binding protein	-
C7A04_RS15660	2930812..2931834	+	1023	WP_001368084.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• Antitoxin PemI-like (1-83)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12511.45 Da
• Isoelectric Point: 5.6219

>T99633 WP_000239579.1 NZ_CP027586:2926930-2927280 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T99633 NZ_CP027586:2926930-2927280 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9299.64 Da
• Isoelectric Point: 4.4201

>AT99633 WP_106913399.1 NZ_CP027586:2926685-2926936 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAVELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT99633 NZ_CP027586:2926685-2926936 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGTGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Toxin

• AlphaFold DB: A0A0E0Y8A8