Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2229744..2230545 Replicon chromosome
Accession NZ_CP027586
Organism Escherichia coli strain 2012EL-2448

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H0JYG3
Locus tag C7A04_RS12065 Protein ID WP_001094432.1
Coordinates 2230168..2230545 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7NA60
Locus tag C7A04_RS12060 Protein ID WP_001380152.1
Coordinates 2229744..2230121 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7A04_RS12025 2226395..2226856 + 462 WP_000581501.1 hypothetical protein -
C7A04_RS28535 2226968..2227179 - 212 Protein_2187 hypothetical protein -
C7A04_RS12035 2227259..2228080 + 822 WP_001241714.1 DUF945 domain-containing protein -
C7A04_RS12040 2228080..2228280 + 201 WP_001367430.1 hypothetical protein -
C7A04_RS12045 2228414..2228887 + 474 WP_000855069.1 antirestriction protein -
C7A04_RS12050 2228902..2229378 + 477 WP_001186704.1 RadC family protein -
C7A04_RS12055 2229447..2229668 + 222 WP_000692313.1 DUF987 domain-containing protein -
C7A04_RS12060 2229744..2230121 + 378 WP_001380152.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
C7A04_RS12065 2230168..2230545 + 378 WP_001094432.1 TA system toxin CbtA family protein Toxin
C7A04_RS12070 2230542..2231030 + 489 WP_032308658.1 hypothetical protein -
C7A04_RS12075 2231042..2231239 + 198 WP_000839249.1 DUF957 domain-containing protein -
C7A04_RS12080 2231324..2232169 + 846 WP_001280530.1 DUF4942 domain-containing protein -
C7A04_RS12095 2232961..2234145 + 1185 WP_001172876.1 sugar efflux transporter -
C7A04_RS12100 2234256..2235179 + 924 WP_000535960.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14136.99 Da        Isoelectric Point: 6.4729

>T99629 WP_001094432.1 NZ_CP027586:2230168-2230545 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T99629 NZ_CP027586:2230168-2230545 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGTCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13679.52 Da        Isoelectric Point: 5.8682

>AT99629 WP_001380152.1 NZ_CP027586:2229744-2230121 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp

>AT99629 NZ_CP027586:2229744-2230121 [Escherichia coli]
GTGTCAGACACACTCCCCGGAACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTAGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0JYG3

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7NA60

References