Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 131629..132107 Replicon chromosome
Accession NZ_CP027586
Organism Escherichia coli strain 2012EL-2448

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag C7A04_RS00850 Protein ID WP_032351442.1
Coordinates 131820..132107 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID -
Locus tag C7A04_RS00845 Protein ID WP_000100897.1
Coordinates 131629..131820 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7A04_RS00800 126889..127452 - 564 WP_001226810.1 ead/Ea22-like family protein -
C7A04_RS00805 127439..127744 - 306 WP_032298829.1 DUF4406 domain-containing protein -
C7A04_RS00810 127741..128022 - 282 WP_072094476.1 DNA-binding protein -
C7A04_RS00815 128055..128816 - 762 WP_000450654.1 DUF1627 domain-containing protein -
C7A04_RS00820 128850..129392 - 543 WP_074015090.1 replication protein -
C7A04_RS28080 129304..130341 - 1038 WP_042969574.1 phage replisome organiser -
C7A04_RS00830 130410..130835 - 426 WP_000693925.1 Rha family transcriptional regulator -
C7A04_RS00835 130819..131091 - 273 WP_000887454.1 helix-turn-helix domain-containing protein -
C7A04_RS00840 131200..131601 + 402 WP_000986593.1 helix-turn-helix domain-containing protein -
C7A04_RS00845 131629..131820 + 192 WP_000100897.1 hypothetical protein Antitoxin
C7A04_RS00850 131820..132107 + 288 WP_032351442.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C7A04_RS00855 132381..132533 + 153 WP_000380312.1 DUF1391 family protein -
C7A04_RS00870 133029..133883 + 855 WP_000935583.1 Rha family phage regulatory protein -
C7A04_RS00875 133894..134082 + 189 WP_000449173.1 cell division inhibitor -
C7A04_RS00880 134079..134267 + 189 WP_000199478.1 DUF1482 family protein -
C7A04_RS00885 134360..136804 + 2445 WP_106913345.1 exonuclease -
C7A04_RS00890 136863..137066 + 204 WP_000096347.1 DUF4224 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - stx2B / stx2A 85551..150541 64990


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10962.84 Da        Isoelectric Point: 10.1360

>T99623 WP_032351442.1 NZ_CP027586:131820-132107 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHARRQFPFSI

Download         Length: 288 bp

>T99623 NZ_CP027586:131820-132107 [Escherichia coli]
ATGTTGCCCATTTTATGGCTACCATCTGCTCGCGATGATTTGCGTCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCGCGTAGACTTAAAATACGTATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACCTATATCCACCAAGCG
AACGGGTTTCTGGGTTGAGAGAGATAGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATGCTCGCCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7013.82 Da        Isoelectric Point: 4.0270

>AT99623 WP_000100897.1 NZ_CP027586:131629-131820 [Escherichia coli]
MSTALSPIVSEFETIEQENSYNEWLRAKVASSLADPRPAIPHDEVIAEMENLIAQIAVTNRSE

Download         Length: 192 bp

>AT99623 NZ_CP027586:131629-131820 [Escherichia coli]
ATGAGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTATCGAACAAGAAAACAGTTACAACGAATGGTTGCGCGC
TAAAGTAGCGTCAAGCCTTGCAGACCCTCGCCCCGCAATTCCACATGACGAGGTAATAGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAGGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References