Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 112116..113699 Replicon chromosome
Accession NZ_CP027562
Organism Stenotrophomonas maltophilia strain SJTH1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag C6Y55_RS00460 Protein ID WP_106466689.1
Coordinates 112116..113438 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag C6Y55_RS00465 Protein ID WP_106466690.1
Coordinates 113442..113699 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6Y55_RS00440 107443..109077 - 1635 WP_106466687.1 TldD/PmbA family protein -
C6Y55_RS00445 109108..110739 - 1632 WP_199792484.1 TldD/PmbA family protein -
C6Y55_RS00455 111501..112115 + 615 WP_106466688.1 DUF938 domain-containing protein -
C6Y55_RS00460 112116..113438 - 1323 WP_106466689.1 type II toxin-antitoxin system HipA family toxin Toxin
C6Y55_RS00465 113442..113699 - 258 WP_106466690.1 helix-turn-helix transcriptional regulator Antitoxin
C6Y55_RS00470 113857..117543 - 3687 WP_106466691.1 indolepyruvate ferredoxin oxidoreductase family protein -
C6Y55_RS00475 117712..118347 + 636 WP_106466692.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48867.66 Da        Isoelectric Point: 7.0478

>T99469 WP_106466689.1 NZ_CP027562:c113438-112116 [Stenotrophomonas maltophilia]
MGTLRVWMNGVEVALWDDVRSGSSRLSYVDSWISSAQSRPLSLSLPLLPKGESHRGNVVNNYFDNLLPDNAVIRNRIRDR
FSTRSSDTFDLLEAIGRDCVGAVQLLPLSHTPGDIQQITCEALDESGVAAILRQVTAGNLPGAPTSDDAFRISIAGAQEK
TGLLLHAGQWCIPTGSTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMQLLSAFGIPVANTQMGRFKDERALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVTIMDLLRQSEHFEDRATFFKTQILFWMLAATDGHAKNFSVYLE
ADGRFRLTPVYDVLSVHPILGRGPNQLDPRNAQLAMSVQGKNRHRKLHLVRRRHWNETARACGVADGAEPWIEALIAAVE
PAIEQVTRQLPSDFPVNVSEPIFNGLRAAAARLSSMSPDA

Download         Length: 1323 bp

>T99469 NZ_CP027562:c113438-112116 [Stenotrophomonas maltophilia]
ATGGGTACGCTGCGGGTCTGGATGAATGGTGTCGAGGTCGCGCTCTGGGATGATGTCCGGAGCGGCTCTTCCCGGCTTTC
GTACGTCGACTCGTGGATCAGCTCCGCCCAGTCCCGGCCGTTGTCGCTCTCACTGCCCCTGCTCCCGAAGGGTGAGAGCC
ATCGGGGCAATGTCGTCAACAACTACTTCGACAACCTTCTTCCCGACAACGCCGTCATCCGCAACCGGATCCGCGACAGG
TTCTCCACGCGCAGCAGCGACACATTCGATCTTCTCGAAGCCATTGGCCGGGATTGCGTCGGCGCAGTGCAACTGCTGCC
GCTTTCGCATACACCGGGGGACATCCAGCAGATTACGTGCGAAGCGTTGGATGAATCAGGCGTCGCTGCGATCCTGCGTC
AGGTGACGGCAGGGAATCTACCTGGCGCACCCACCAGTGATGATGCGTTCCGCATATCCATCGCCGGTGCGCAGGAGAAG
ACGGGACTTCTGCTGCATGCTGGCCAGTGGTGCATTCCTACCGGCAGTACCCCATCCACCCATATCTTCAAGCTGCCGCT
TGGCATTGTGGGCAACATGCGGGCGGACATGCACCAATCCGTCGAGAACGAATGGCTGTGCATGCAACTGCTTTCCGCCT
TTGGAATCCCCGTTGCGAATACGCAGATGGGACGCTTCAAGGACGAACGCGCGCTTATTGTGGAGCGATTCGACCGCCGC
CTTTCTGCGGATCGCCGGTGGTGGCTGCGGCTGCCGCAGGAAGACATGTGCCAGGTCTTCGGTCTGCCCGCTGCCAGGAA
GTATGAATCCGATGGCGGCCCAGGCATCGTGACCATCATGGATCTGCTTCGACAATCCGAGCATTTCGAGGATCGGGCGA
CCTTCTTCAAGACGCAGATTCTTTTCTGGATGTTGGCTGCAACCGATGGACATGCCAAGAACTTCAGTGTCTACCTCGAA
GCGGATGGACGCTTCCGCCTGACGCCCGTCTACGACGTATTGTCGGTGCATCCCATCCTGGGTAGGGGGCCAAACCAGCT
CGACCCGCGGAATGCACAGCTCGCCATGTCCGTCCAGGGCAAGAACCGCCACCGGAAGCTGCACCTTGTGCGACGACGCC
ACTGGAACGAAACAGCACGCGCCTGTGGTGTCGCTGATGGTGCGGAGCCGTGGATCGAAGCGCTGATTGCAGCCGTCGAA
CCCGCCATCGAGCAGGTCACGCGTCAGCTCCCAAGTGATTTCCCCGTAAACGTGTCCGAACCCATTTTCAACGGGCTGCG
CGCTGCGGCGGCACGCCTTTCCAGCATGTCGCCGGACGCCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 11.8979

>AT99469 WP_106466690.1 NZ_CP027562:c113699-113442 [Stenotrophomonas maltophilia]
MDRPLHTVRTPQQLAPLMRAFRRQAGLSQAQLAAQLGISRQAVGALERDPASASFERLMRVWAVLGLEVSLQQRSPPETT
PTLEW

Download         Length: 258 bp

>AT99469 NZ_CP027562:c113699-113442 [Stenotrophomonas maltophilia]
ATGGACAGGCCGCTGCACACGGTGAGGACACCTCAACAACTGGCACCGCTGATGCGTGCGTTCAGGCGCCAGGCGGGCCT
GAGCCAGGCGCAGTTGGCGGCACAGCTCGGCATAAGCCGCCAGGCAGTAGGCGCATTGGAGCGCGACCCGGCATCGGCAA
GCTTCGAACGGCTGATGCGGGTCTGGGCAGTGCTGGGTCTGGAAGTCAGTTTGCAGCAGCGAAGTCCCCCGGAGACAACG
CCAACGTTGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References