Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1496346..1496967 Replicon chromosome
Accession NZ_CP027561
Organism Pseudomonas fluorescens strain G7

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C6Y56_RS06725 Protein ID WP_007957952.1
Coordinates 1496788..1496967 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C6Y56_RS06720 Protein ID WP_085710213.1
Coordinates 1496346..1496753 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6Y56_RS06690 1492439..1492594 + 156 WP_082302357.1 stress protein -
C6Y56_RS06695 1492670..1493173 + 504 WP_085683215.1 DUF4142 domain-containing protein -
C6Y56_RS06700 1493223..1493631 - 409 Protein_1317 low affinity iron permease family protein -
C6Y56_RS06705 1493847..1494617 + 771 WP_169429224.1 trans-aconitate 2-methyltransferase -
C6Y56_RS06710 1494660..1495388 - 729 WP_169429225.1 class I SAM-dependent methyltransferase -
C6Y56_RS06715 1495916..1496284 + 369 WP_169429226.1 hypothetical protein -
C6Y56_RS06720 1496346..1496753 - 408 WP_085710213.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C6Y56_RS06725 1496788..1496967 - 180 WP_007957952.1 type II toxin-antitoxin system HicA family toxin Toxin
C6Y56_RS06735 1497654..1498538 - 885 WP_169429227.1 alpha/beta hydrolase -
C6Y56_RS06740 1498855..1499547 - 693 WP_169429228.1 pseudouridine synthase -
C6Y56_RS06745 1499581..1499799 - 219 WP_169429229.1 cysteine-rich CWC family protein -
C6Y56_RS06750 1499805..1501292 - 1488 WP_169429230.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6660.91 Da        Isoelectric Point: 11.4113

>T99464 WP_007957952.1 NZ_CP027561:c1496967-1496788 [Pseudomonas fluorescens]
VNSRFLIGQLVADGWYLVRVRGSHHHFKHPTKPGLVTVPHPKKDLLKKTAISILQQALL

Download         Length: 180 bp

>T99464 NZ_CP027561:c1496967-1496788 [Pseudomonas fluorescens]
GTGAACAGCCGTTTTCTAATTGGCCAGCTCGTCGCAGACGGTTGGTATCTGGTGCGGGTCAGGGGCAGTCATCATCACTT
CAAGCATCCGACCAAACCTGGTCTGGTCACAGTGCCTCACCCGAAGAAGGATCTGCTCAAGAAAACGGCCATCAGCATTT
TGCAACAGGCGCTCCTTTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14542.56 Da        Isoelectric Point: 4.5801

>AT99464 WP_085710213.1 NZ_CP027561:c1496753-1496346 [Pseudomonas fluorescens]
MLYPIAISVGDEGHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGSPIPPANKVTLHAANPKYAGCTWAL
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQG

Download         Length: 408 bp

>AT99464 NZ_CP027561:c1496753-1496346 [Pseudomonas fluorescens]
ATGCTTTACCCGATCGCGATTTCAGTGGGTGACGAAGGACATGCCTGGGGAGTGGAGGTGCCGGATATTCCGGGCTGCTT
CTCCGCTGGAGATGATCTGGATGACGCGATGGCGATGGCCCGCGAAGCCATTGAAGGCCATTTCGAGATTCTGGCCGAGG
ACGGTTCGCCAATCCCGCCAGCCAACAAGGTCACGCTGCATGCCGCCAATCCAAAATACGCTGGCTGCACGTGGGCGTTG
GTGGACATCGATGTAACCAAATACCTGGGCAAAGCTCAGAAACTCAACATCACATTGCCGGGCTACCTGCTGAACCGTAT
TGATGAATACGTGTTGCACCACCCGGAAGAGAAAAGCCGCTCCGGATTCCTGGCCTCGGCGGCGCTCAAGGTGTTGCAGC
AAGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References