Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 3862267..3863255 Replicon chromosome
Accession NZ_CP027550
Organism Escherichia coli strain 2015C-4136CT1

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag C6950_RS20265 Protein ID WP_014640052.1
Coordinates 3862869..3863255 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A0A1AFM1
Locus tag C6950_RS20260 Protein ID WP_000458583.1
Coordinates 3862267..3862839 (+) Length 191 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6950_RS20235 3858429..3858797 + 369 WP_000002899.1 diacylglycerol kinase -
C6950_RS20240 3858907..3859515 + 609 WP_000646078.1 transcriptional repressor LexA -
C6950_RS20245 3859588..3860913 + 1326 WP_001296637.1 MATE family efflux transporter DinF -
C6950_RS20250 3861029..3861238 + 210 WP_001296638.1 CsbD family protein -
C6950_RS20255 3861280..3861795 - 516 WP_000416264.1 zinc uptake transcriptional repressor Zur -
C6950_RS20260 3862267..3862839 + 573 WP_000458583.1 SocA family protein Antitoxin
C6950_RS20265 3862869..3863255 + 387 WP_014640052.1 hypothetical protein Toxin
C6950_RS26865 3863295..3863468 + 174 WP_021559700.1 hypothetical protein -
C6950_RS20270 3863516..3863797 - 282 WP_001093916.1 pyocin activator PrtN family protein -
C6950_RS20275 3863834..3864406 - 573 WP_021559699.1 3'-5' exoribonuclease -
C6950_RS20280 3864406..3865158 - 753 WP_021559698.1 DUF551 domain-containing protein -
C6950_RS20285 3865161..3865352 - 192 WP_001014291.1 hypothetical protein -
C6950_RS26870 3865354..3865539 - 186 Protein_3723 ead/Ea22-like family protein -
C6950_RS26875 3865651..3865882 - 232 Protein_3724 ead/Ea22-like family protein -
C6950_RS20295 3865879..3866118 - 240 WP_000476214.1 hypothetical protein -
C6950_RS20300 3866111..3866314 - 204 WP_000111289.1 hypothetical protein -
C6950_RS20305 3866311..3866673 - 363 WP_021559696.1 phage protein -
C6950_RS20310 3866664..3867200 - 537 WP_000008178.1 5'-deoxynucleotidase -
C6950_RS20315 3867329..3868153 - 825 WP_106878848.1 YfdQ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-137)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T99383 WP_014640052.1 NZ_CP027550:3862869-3863255 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T99383 NZ_CP027550:3862869-3863255 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCCGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin


Download         Length: 191 a.a.        Molecular weight: 21956.30 Da        Isoelectric Point: 6.0283

>AT99383 WP_000458583.1 NZ_CP027550:3862267-3862839 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHDVLLRSDPREMDADEVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Download         Length: 573 bp

>AT99383 NZ_CP027550:3862267-3862839 [Escherichia coli]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTTCTTAAGCGAGGTGGGCGCATGGCATATCTGAAATT
GATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGAAGATAGCCTTTACTCTA
TGAAATTTGGTCCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGTATTGGTGACTACTGGTACAAC
CTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGACGAGGTCTTTGATGAGTT
GAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATTTGATCTCGCAAACATGA
CGCATTTAGAAAGCGTTTGTCCAGAGTGGCACAATCCTGGCAATTCTCGTAAGCCTATAGACCTGAAAGAAATGCTGATC
AGTGAGGGTAAAAGCGAGGATGAGGCTAATCGTATAATTGGCAAAATGGAAGAATCTCAGAAACTTAAGGAATTTTCTTT
GCAATTATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0A1AFM1

References