99380

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3092641..3093236 Replicon chromosome
Accession NZ_CP027550
Organism Escherichia coli strain 2015C-4136CT1

Toxin (Protein)


Gene name doc Uniprot ID A0A826P6U8
Locus tag C6950_RS16350 Protein ID WP_000155160.1
Coordinates 3092641..3093018 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A827G8B6
Locus tag C6950_RS16355 Protein ID WP_000557316.1
Coordinates 3093015..3093236 (-) Length 74 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6950_RS16330 3088217..3089287 - 1071 WP_001357972.1 sn-glycerol 3-phosphate ABC transporter ATP binding protein UgpC -
C6950_RS16335 3089289..3090134 - 846 WP_000572183.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
C6950_RS16340 3090131..3091018 - 888 WP_000099282.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
C6950_RS16345 3091116..3092432 - 1317 WP_000803589.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
C6950_RS16350 3092641..3093018 - 378 WP_000155160.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
C6950_RS16355 3093015..3093236 - 222 WP_000557316.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C6950_RS16360 3093324..3094037 - 714 WP_000416895.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
C6950_RS16365 3094039..3094806 - 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
C6950_RS16370 3094803..3096080 - 1278 WP_000803800.1 branched chain amino acid ABC transporter permease LivM -
C6950_RS16375 3096077..3097003 - 927 WP_001295101.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
C6950_RS16380 3097051..3098160 - 1110 WP_001297972.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3087477..3097003 9526


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 13945.20 Da        Isoelectric Point: 6.4830

>T99380 WP_000155160.1 NZ_CP027550:c3093018-3092641 [Escherichia coli]
MTIQFISAEEIIYFHDKLLSVTPGVTGMSDPGRAEALLYRVLNKYEYEGVSDLWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGLILAANPEFVELTVDVAAGKVSLEDIVTRLRQHGT

Download         Length: 378 bp

>T99380 NZ_CP027550:c3093018-3092641 [Escherichia coli]
ATGACCATTCAGTTTATCTCTGCGGAGGAGATAATTTATTTCCACGATAAGTTGCTTAGCGTTACACCAGGTGTAACAGG
AATGTCCGATCCAGGGCGAGCAGAAGCGCTTTTGTACCGGGTACTGAATAAGTACGAGTATGAAGGCGTTTCCGATCTTT
GGCTGCTGGCGGCGATGCATCTATTGGCAATCTCGCGCGGTCATATTTTTAATGATGGTAATAAGCGCACCGCACTGTTT
ATCACGCTATTATTCCTTAAACGTAACGGCCTCATACTTGCTGCAAACCCAGAGTTTGTGGAATTGACGGTTGATGTGGC
GGCGGGAAAAGTATCGTTAGAAGATATCGTTACCCGCTTGCGTCAACACGGAACCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8106.25 Da        Isoelectric Point: 5.5759

>AT99380 WP_000557316.1 NZ_CP027550:c3093236-3093015 [Escherichia coli]
MHTMNYSEARQNLALVLETAATGTPVTITRRGHKAAVIISAEEFERYQKAKLDAEFDAIMAIHGSEIMELADK

Download         Length: 222 bp

>AT99380 NZ_CP027550:c3093236-3093015 [Escherichia coli]
ATGCATACCATGAACTACAGCGAAGCGCGACAGAACCTTGCATTGGTTCTGGAAACAGCGGCGACAGGTACTCCGGTAAC
GATCACGAGGCGTGGGCATAAGGCCGCTGTGATTATTAGCGCAGAAGAGTTTGAACGTTACCAGAAGGCTAAACTGGACG
CGGAATTTGACGCCATCATGGCTATTCATGGCAGCGAAATTATGGAGTTAGCGGATAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A826P6U8


Antitoxin

Source ID Structure
AlphaFold DB A0A827G8B6

References