Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
Location | 3092641..3093236 | Replicon | chromosome |
Accession | NZ_CP027550 | ||
Organism | Escherichia coli strain 2015C-4136CT1 |
Toxin (Protein)
Gene name | doc | Uniprot ID | A0A826P6U8 |
Locus tag | C6950_RS16350 | Protein ID | WP_000155160.1 |
Coordinates | 3092641..3093018 (-) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | A0A827G8B6 |
Locus tag | C6950_RS16355 | Protein ID | WP_000557316.1 |
Coordinates | 3093015..3093236 (-) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C6950_RS16330 | 3088217..3089287 | - | 1071 | WP_001357972.1 | sn-glycerol 3-phosphate ABC transporter ATP binding protein UgpC | - |
C6950_RS16335 | 3089289..3090134 | - | 846 | WP_000572183.1 | sn-glycerol-3-phosphate ABC transporter permease UgpE | - |
C6950_RS16340 | 3090131..3091018 | - | 888 | WP_000099282.1 | sn-glycerol-3-phosphate ABC transporter permease UgpA | - |
C6950_RS16345 | 3091116..3092432 | - | 1317 | WP_000803589.1 | sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB | - |
C6950_RS16350 | 3092641..3093018 | - | 378 | WP_000155160.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
C6950_RS16355 | 3093015..3093236 | - | 222 | WP_000557316.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
C6950_RS16360 | 3093324..3094037 | - | 714 | WP_000416895.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF | - |
C6950_RS16365 | 3094039..3094806 | - | 768 | WP_000082101.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
C6950_RS16370 | 3094803..3096080 | - | 1278 | WP_000803800.1 | branched chain amino acid ABC transporter permease LivM | - |
C6950_RS16375 | 3096077..3097003 | - | 927 | WP_001295101.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
C6950_RS16380 | 3097051..3098160 | - | 1110 | WP_001297972.1 | high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 3087477..3097003 | 9526 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13945.20 Da Isoelectric Point: 6.4830
>T99380 WP_000155160.1 NZ_CP027550:c3093018-3092641 [Escherichia coli]
MTIQFISAEEIIYFHDKLLSVTPGVTGMSDPGRAEALLYRVLNKYEYEGVSDLWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGLILAANPEFVELTVDVAAGKVSLEDIVTRLRQHGT
MTIQFISAEEIIYFHDKLLSVTPGVTGMSDPGRAEALLYRVLNKYEYEGVSDLWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGLILAANPEFVELTVDVAAGKVSLEDIVTRLRQHGT
Download Length: 378 bp
>T99380 NZ_CP027550:c3093018-3092641 [Escherichia coli]
ATGACCATTCAGTTTATCTCTGCGGAGGAGATAATTTATTTCCACGATAAGTTGCTTAGCGTTACACCAGGTGTAACAGG
AATGTCCGATCCAGGGCGAGCAGAAGCGCTTTTGTACCGGGTACTGAATAAGTACGAGTATGAAGGCGTTTCCGATCTTT
GGCTGCTGGCGGCGATGCATCTATTGGCAATCTCGCGCGGTCATATTTTTAATGATGGTAATAAGCGCACCGCACTGTTT
ATCACGCTATTATTCCTTAAACGTAACGGCCTCATACTTGCTGCAAACCCAGAGTTTGTGGAATTGACGGTTGATGTGGC
GGCGGGAAAAGTATCGTTAGAAGATATCGTTACCCGCTTGCGTCAACACGGAACCTGA
ATGACCATTCAGTTTATCTCTGCGGAGGAGATAATTTATTTCCACGATAAGTTGCTTAGCGTTACACCAGGTGTAACAGG
AATGTCCGATCCAGGGCGAGCAGAAGCGCTTTTGTACCGGGTACTGAATAAGTACGAGTATGAAGGCGTTTCCGATCTTT
GGCTGCTGGCGGCGATGCATCTATTGGCAATCTCGCGCGGTCATATTTTTAATGATGGTAATAAGCGCACCGCACTGTTT
ATCACGCTATTATTCCTTAAACGTAACGGCCTCATACTTGCTGCAAACCCAGAGTTTGTGGAATTGACGGTTGATGTGGC
GGCGGGAAAAGTATCGTTAGAAGATATCGTTACCCGCTTGCGTCAACACGGAACCTGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8106.25 Da Isoelectric Point: 5.5759
>AT99380 WP_000557316.1 NZ_CP027550:c3093236-3093015 [Escherichia coli]
MHTMNYSEARQNLALVLETAATGTPVTITRRGHKAAVIISAEEFERYQKAKLDAEFDAIMAIHGSEIMELADK
MHTMNYSEARQNLALVLETAATGTPVTITRRGHKAAVIISAEEFERYQKAKLDAEFDAIMAIHGSEIMELADK
Download Length: 222 bp
>AT99380 NZ_CP027550:c3093236-3093015 [Escherichia coli]
ATGCATACCATGAACTACAGCGAAGCGCGACAGAACCTTGCATTGGTTCTGGAAACAGCGGCGACAGGTACTCCGGTAAC
GATCACGAGGCGTGGGCATAAGGCCGCTGTGATTATTAGCGCAGAAGAGTTTGAACGTTACCAGAAGGCTAAACTGGACG
CGGAATTTGACGCCATCATGGCTATTCATGGCAGCGAAATTATGGAGTTAGCGGATAAATGA
ATGCATACCATGAACTACAGCGAAGCGCGACAGAACCTTGCATTGGTTCTGGAAACAGCGGCGACAGGTACTCCGGTAAC
GATCACGAGGCGTGGGCATAAGGCCGCTGTGATTATTAGCGCAGAAGAGTTTGAACGTTACCAGAAGGCTAAACTGGACG
CGGAATTTGACGCCATCATGGCTATTCATGGCAGCGAAATTATGGAGTTAGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A826P6U8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A827G8B6 |