Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2463327..2463805 Replicon chromosome
Accession NZ_CP027548
Organism Escherichia coli strain 2014C-3061

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag C6992_RS13575 Protein ID WP_001303876.1
Coordinates 2463518..2463805 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag C6992_RS13570 Protein ID WP_000536233.1
Coordinates 2463327..2463518 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6992_RS13535 2458707..2459477 - 771 WP_000451007.1 DUF1627 domain-containing protein -
C6992_RS13540 2459499..2460245 - 747 WP_000788742.1 ATP-binding protein -
C6992_RS13545 2460252..2461367 - 1116 WP_001205821.1 hypothetical protein -
C6992_RS13550 2461446..2461901 + 456 WP_000273724.1 hypothetical protein -
C6992_RS13555 2462108..2462533 - 426 WP_000693855.1 Rha family transcriptional regulator -
C6992_RS13560 2462517..2462789 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
C6992_RS13565 2462898..2463299 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
C6992_RS13570 2463327..2463518 + 192 WP_000536233.1 hypothetical protein Antitoxin
C6992_RS13575 2463518..2463805 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6992_RS13580 2464082..2464234 + 153 WP_000380316.1 DUF1391 family protein -
C6992_RS13585 2464246..2464884 + 639 WP_000394543.1 hypothetical protein -
C6992_RS13590 2464885..2465094 - 210 WP_001133037.1 hypothetical protein -
C6992_RS13600 2465662..2465850 + 189 WP_000413705.1 cell division inhibition protein DicB -
C6992_RS13605 2465847..2466038 + 192 WP_001098307.1 DUF1482 family protein -
C6992_RS13610 2466132..2468582 + 2451 WP_009448824.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T99351 WP_001303876.1 NZ_CP027548:2463518-2463805 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T99351 NZ_CP027548:2463518-2463805 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT99351 WP_000536233.1 NZ_CP027548:2463327-2463518 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT99351 NZ_CP027548:2463327-2463518 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References