Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1419334..1419977 Replicon chromosome
Accession NZ_CP027541
Organism Mycolicibacterium smegmatis MKD8

Toxin (Protein)


Gene name vapC Uniprot ID A0A2U9PKL6
Locus tag D806_RS06525 Protein ID WP_036452755.1
Coordinates 1419588..1419977 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0QRY5
Locus tag D806_RS06520 Protein ID WP_003892665.1
Coordinates 1419334..1419588 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D806_RS06510 1414764..1418147 + 3384 WP_003892663.1 ATP-binding protein -
D806_RS06515 1418144..1419313 + 1170 WP_003892664.1 DUF3322 and DUF2220 domain-containing protein -
D806_RS06520 1419334..1419588 + 255 WP_003892665.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
D806_RS06525 1419588..1419977 + 390 WP_036452755.1 type II toxin-antitoxin system VapC family toxin Toxin
D806_RS06530 1419996..1422401 - 2406 WP_036452757.1 SEC-C domain-containing protein -
D806_RS06535 1422423..1424183 - 1761 WP_003892668.1 sulfatase-like hydrolase/transferase -
D806_RS06540 1424180..1424617 - 438 WP_011727567.1 SRPBCC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13953.74 Da        Isoelectric Point: 4.5959

>T99269 WP_036452755.1 NZ_CP027541:1419588-1419977 [Mycolicibacterium smegmatis MKD8]
MVIDTSALVAILTDEPDAELLEGAVADDPVRTMSTASYLETAIVIESRFGEPGGRELDLWLHRASVALVAVDADQADAAR
LAYRRYGKGRHRAGLNYGDCFSYALAKVSGQPLLFKGEDFRLTDVAAVH

Download         Length: 390 bp

>T99269 NZ_CP027541:1419588-1419977 [Mycolicibacterium smegmatis MKD8]
ATGGTTATCGACACTTCTGCCCTCGTTGCCATCTTGACCGACGAACCCGACGCTGAGTTGTTGGAGGGGGCGGTGGCTGA
CGATCCTGTTCGGACTATGTCCACCGCGTCGTATCTGGAGACAGCGATCGTGATCGAAAGTCGCTTCGGCGAGCCAGGTG
GTCGCGAACTCGATCTGTGGTTGCATCGCGCATCAGTGGCACTGGTCGCTGTGGATGCCGATCAGGCCGACGCCGCCCGG
TTGGCTTACCGGAGATACGGCAAGGGGCGCCATCGTGCAGGCCTGAATTACGGCGACTGTTTTTCCTATGCGCTCGCCAA
GGTCAGCGGTCAGCCTTTGTTGTTCAAGGGTGAGGATTTTCGGCTCACCGACGTCGCTGCGGTCCACTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9279.72 Da        Isoelectric Point: 8.0238

>AT99269 WP_003892665.1 NZ_CP027541:1419334-1419588 [Mycolicibacterium smegmatis MKD8]
MALSIKHPEADRLARELAARTGETLTEAVVMALRERLARTVGRTQVVPLREELAAIRRRCAALPVLDDRTAESILGYDDR
GLPS

Download         Length: 255 bp

>AT99269 NZ_CP027541:1419334-1419588 [Mycolicibacterium smegmatis MKD8]
ATGGCTCTGAGCATCAAACACCCGGAAGCCGACCGGCTGGCCAGAGAGCTAGCGGCACGTACGGGGGAGACACTGACCGA
GGCGGTGGTGATGGCACTGCGGGAGCGACTGGCGCGCACTGTCGGGCGCACTCAGGTCGTTCCGCTTCGTGAGGAACTCG
CCGCGATCCGTCGTCGCTGCGCAGCCCTACCGGTGTTGGACGACCGGACAGCCGAATCGATCCTGGGCTACGACGACCGC
GGTCTGCCGTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U9PKL6

Antitoxin

Source ID Structure
AlphaFold DB A0QRY5

References