Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 1412106..1412689 Replicon chromosome
Accession NZ_CP027541
Organism Mycolicibacterium smegmatis MKD8

Toxin (Protein)


Gene name doc Uniprot ID A0A2U9PKR4
Locus tag D806_RS06495 Protein ID WP_003892660.1
Coordinates 1412300..1412689 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2U9PKT9
Locus tag D806_RS06490 Protein ID WP_011727559.1
Coordinates 1412106..1412303 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D806_RS06465 1407143..1408618 - 1476 WP_003892654.1 ADP-ribosylglycohydrolase family protein -
D806_RS06470 1408806..1409147 - 342 WP_011727555.1 DUF732 domain-containing protein -
D806_RS06475 1409207..1410334 - 1128 WP_003892656.1 SMP-30/gluconolactonase/LRE family protein -
D806_RS06480 1410515..1411594 - 1080 WP_003892657.1 HNH endonuclease -
D806_RS06485 1411662..1411958 + 297 WP_003892658.1 nucleoside triphosphate pyrophosphohydrolase -
D806_RS06490 1412106..1412303 + 198 WP_011727559.1 type II toxin-antitoxin system antitoxin Phd Antitoxin
D806_RS06495 1412300..1412689 + 390 WP_003892660.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
D806_RS06500 1412766..1414196 + 1431 WP_003892661.1 DUF3375 domain-containing protein -
D806_RS06505 1414193..1414771 + 579 WP_003892662.1 DUF4194 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(18-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13868.49 Da        Isoelectric Point: 4.2481

>T99268 WP_003892660.1 NZ_CP027541:1412300-1412689 [Mycolicibacterium smegmatis MKD8]
VTEYLDREDVLTAGSIAFGGELKVRDYGLLDAAVARPQATVYGVDAYPRLWDKAAALLQSLARNHALVDGNKRTAWAAAW
TFLHINGVQLAADFDVDRAEDLMNEVATRDCDLDSIAAELAGFAAAQTG

Download         Length: 390 bp

>T99268 NZ_CP027541:1412300-1412689 [Mycolicibacterium smegmatis MKD8]
GTGACCGAGTACCTCGACCGCGAGGACGTGCTCACCGCGGGATCGATCGCTTTTGGCGGCGAGCTGAAGGTGCGGGACTA
CGGACTGCTCGACGCTGCGGTTGCCCGCCCGCAGGCCACGGTGTATGGCGTGGATGCGTACCCGCGGCTGTGGGACAAGG
CCGCTGCGTTGTTGCAGTCCCTGGCGCGGAACCATGCGCTGGTCGACGGTAACAAGCGCACTGCGTGGGCTGCGGCATGG
ACATTTCTGCACATCAACGGTGTACAGCTGGCGGCTGATTTCGATGTCGATCGCGCGGAGGACCTCATGAACGAGGTGGC
CACCCGTGACTGCGACCTGGATTCCATCGCCGCCGAGCTGGCCGGTTTCGCCGCTGCGCAGACGGGGTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7276.30 Da        Isoelectric Point: 8.9353

>AT99268 WP_011727559.1 NZ_CP027541:1412106-1412303 [Mycolicibacterium smegmatis MKD8]
MPSLNIDFDEAEMEQIRAAARADDLSLKKFAHAAVMERASAHKRRVAEAARLVAERSAELNRRLA

Download         Length: 198 bp

>AT99268 NZ_CP027541:1412106-1412303 [Mycolicibacterium smegmatis MKD8]
ATGCCGTCGCTGAACATCGACTTCGACGAAGCCGAGATGGAACAGATCCGCGCTGCTGCCCGGGCGGATGACCTGTCGCT
GAAGAAGTTCGCGCACGCCGCCGTGATGGAGCGTGCCAGCGCGCACAAGCGCAGGGTCGCCGAGGCGGCGCGTCTGGTCG
CTGAGCGTTCGGCTGAGCTCAACCGCCGCTTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U9PKR4

Antitoxin

Source ID Structure
AlphaFold DB A0A2U9PKT9

References