Detailed information of TA system TA099246

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 965095..965630
• Replicon: chromosome
• Accession: NZ_CP027539
• Organism: Serratia marcescens strain AR_0099

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AM478_RS04600
• Protein ID: WP_033649525.1
• Coordinates: 965095..965370 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: AM478_RS04605
• Protein ID: WP_033649526.1
• Coordinates: 965370..965630 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM478_RS04580	960913..961905	-	993	WP_033649523.1	acyltransferase	-
AM478_RS04585	962123..963370	+	1248	WP_033649577.1	MFS transporter	-
AM478_RS04590	963424..964050	-	627	WP_033649524.1	LysE family translocator	-
AM478_RS04595	964172..965083	+	912	WP_033636572.1	LysR family transcriptional regulator	-
AM478_RS04600	965095..965370	-	276	WP_033649525.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AM478_RS04605	965370..965630	-	261	WP_033649526.1	ribbon-helix-helix domain-containing protein	Antitoxin
AM478_RS04610	965713..967554	-	1842	WP_033649527.1	selenocysteine-specific translation elongation factor	-
AM478_RS04615	967551..968945	-	1395	WP_033649528.1	L-seryl-tRNA(Sec) selenium transferase	-
AM478_RS04620	969015..969620	-	606	WP_033649529.1	glutathione S-transferase	-
AM478_RS04625	969661..970311	-	651	WP_033649530.1	DcrB-related protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10596.34 Da
• Isoelectric Point: 10.3377

>T99246 WP_033649525.1 NZ_CP027539:c965370-965095 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALVNRTAAANSVKALVAAPKALLDNSRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Nucleotide

• Length: 276 bp

>T99246 NZ_CP027539:c965370-965095 [Serratia marcescens]
ATGGAGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGTTAACCGTACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTTGATAATTCTCGCCTGGGTGAAAGACTGGACG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9698.01 Da
• Isoelectric Point: 4.5201

>AT99246 WP_033649526.1 NZ_CP027539:c965630-965370 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALTAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Nucleotide

• Length: 261 bp

>AT99246 NZ_CP027539:c965630-965370 [Serratia marcescens]
ATGAATACGAAAGTCATCACCGCTCATGTCCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
CTCACGGGGATGGATAGTGAAGCAAGCCCTCACCGCCTGGCTCGAGCAAGAGGAAGAGCGTCGTCGGTTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAATCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAT
CCGCTGCCGGTACCGCGCTGA