Detailed information of TA system TA099244

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 401557..402260
• Replicon: chromosome
• Accession: NZ_CP027539
• Organism: Serratia marcescens strain AR_0099

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A6S5XK15
• Locus tag: AM478_RS01870
• Protein ID: WP_071998139.1
• Coordinates: 401557..401898 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: AM478_RS01875
• Protein ID: WP_071998140.1
• Coordinates: 401919..402260 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM478_RS01865	400292..401299	-	1008	WP_001757896.1	restriction endonuclease	-
AM478_RS01870	401557..401898	-	342	WP_071998139.1	TA system toxin CbtA family protein	Toxin
AM478_RS01875	401919..402260	-	342	WP_071998140.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
AM478_RS01880	402271..402813	-	543	WP_033648598.1	DNA repair protein RadC	-
AM478_RS01885	402826..403266	-	441	WP_033648599.1	antirestriction protein	-
AM478_RS01890	403297..404118	-	822	WP_033648600.1	DUF945 domain-containing protein	-
AM478_RS01895	404217..404447	-	231	WP_033648602.1	DUF905 domain-containing protein	-
AM478_RS01900	404519..404968	-	450	WP_033648603.1	hypothetical protein	-
AM478_RS01905	404965..405417	-	453	WP_033648605.1	hypothetical protein	-
AM478_RS01910	405454..406023	-	570	WP_033648606.1	hypothetical protein	-
AM478_RS01915	406023..406727	-	705	WP_071998141.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-109)

Antitoxin

• Antitoxin CbeA (13-111)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12710.63 Da
• Isoelectric Point: 6.4514

>T99244 WP_071998139.1 NZ_CP027539:c401898-401557 [Serratia marcescens]
MKTLPATTPQAATLCLSPVAVWQMLLACLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYELVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAQ

Nucleotide

• Length: 342 bp

>T99244 NZ_CP027539:c401898-401557 [Serratia marcescens]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGACGCTATGTCTGTCGCCCGTAGCAGTGTGGCAAATGCTGCTTGC
ATGCCTGCTGGAACAACATTATGGCCTTACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGAACTGGTTCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCAGTAGATATTCTGCGGGCGCGGCAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACAGTGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12799.28 Da
• Isoelectric Point: 5.0589

>AT99244 WP_071998140.1 NZ_CP027539:c402260-401919 [Serratia marcescens]
MKSTDSENDSFLQWGLNRNVTPCFGARLVQEGNRLHYLVDRASITGEFSNAESLKLDEVFPHFISQMESMLATGEMNPCH
DHCVTLYHNGFTCEADTLGSYGYVYIAVYPTHR

Nucleotide

• Length: 342 bp

>AT99244 NZ_CP027539:c402260-401919 [Serratia marcescens]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCCAGTGGGGGCTGAATCGTAATGTGACGCCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCTGGTTGACCGGGCCAGCATTACCGGTGAATTCAGTAACGCAGAATCTT
TGAAGTTGGATGAAGTATTCCCACATTTTATCAGCCAGATGGAGTCGATGTTGGCTACTGGTGAAATGAATCCTTGCCAT
GACCACTGTGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CGTTTACCCCACTCATCGTTAA

Structures

Toxin

• AlphaFold DB: A0A6S5XK15