Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4988910..4989445 Replicon chromosome
Accession NZ_CP027533
Organism Serratia marcescens strain AR_0091

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag AM470_RS23935 Protein ID WP_060429050.1
Coordinates 4989170..4989445 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag AM470_RS23930 Protein ID WP_033649526.1
Coordinates 4988910..4989170 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM470_RS23910 4984229..4984879 + 651 WP_033636562.1 DcrB-related protein -
AM470_RS23915 4984920..4985525 + 606 WP_033649529.1 glutathione S-transferase -
AM470_RS23920 4985595..4986989 + 1395 WP_060429046.1 L-seryl-tRNA(Sec) selenium transferase -
AM470_RS23925 4986986..4988827 + 1842 WP_060429048.1 selenocysteine-specific translation elongation factor -
AM470_RS23930 4988910..4989170 + 261 WP_033649526.1 ribbon-helix-helix domain-containing protein Antitoxin
AM470_RS23935 4989170..4989445 + 276 WP_060429050.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM470_RS23940 4989457..4990368 - 912 WP_033636572.1 LysR family transcriptional regulator -
AM470_RS23945 4990490..4991116 + 627 WP_047569917.1 LysE family translocator -
AM470_RS23950 4991170..4992417 - 1248 WP_041038165.1 MFS transporter -
AM470_RS23955 4992635..4993627 + 993 WP_049213612.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10535.29 Da        Isoelectric Point: 10.0331

>T99187 WP_060429050.1 NZ_CP027533:4989170-4989445 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREEL

Download         Length: 276 bp

>T99187 NZ_CP027533:4989170-4989445 [Serratia marcescens]
ATGGAGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGTACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTTGATAATCCTCGCCTGGGTGAAAGACTGGACG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCTATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9698.01 Da        Isoelectric Point: 4.5201

>AT99187 WP_033649526.1 NZ_CP027533:4988910-4989170 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALTAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Download         Length: 261 bp

>AT99187 NZ_CP027533:4988910-4989170 [Serratia marcescens]
ATGAATACGAAAGTCATCACCGCTCATGTCCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
CTCACGGGGATGGATAGTGAAGCAAGCCCTCACCGCCTGGCTCGAGCAAGAGGAAGAGCGCCGTCGGTTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAATCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAT
CCGCTGCCGGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References