Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4947991..4948592 Replicon chromosome
Accession NZ_CP027533
Organism Serratia marcescens strain AR_0091

Toxin (Protein)


Gene name vapC Uniprot ID A0A2V4FS51
Locus tag AM470_RS23755 Protein ID WP_033649548.1
Coordinates 4947991..4948371 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2S4X5L5
Locus tag AM470_RS23760 Protein ID WP_039568270.1
Coordinates 4948371..4948592 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM470_RS23730 4943244..4944524 + 1281 WP_041037321.1 DUF3748 domain-containing protein -
AM470_RS23735 4944555..4944902 - 348 WP_049197081.1 YceK/YidQ family lipoprotein -
AM470_RS23740 4945213..4945626 + 414 WP_004933919.1 heat shock chaperone IbpA -
AM470_RS23745 4945727..4946155 + 429 WP_004933922.1 heat shock chaperone IbpB -
AM470_RS23750 4946322..4947980 + 1659 WP_033649549.1 putative transporter -
AM470_RS23755 4947991..4948371 - 381 WP_033649548.1 type II toxin-antitoxin system VapC family toxin Toxin
AM470_RS23760 4948371..4948592 - 222 WP_039568270.1 ribbon-helix-helix protein, CopG family Antitoxin
AM470_RS23765 4948668..4949918 - 1251 WP_060388266.1 valine--pyruvate transaminase -
AM470_RS23770 4950054..4952117 - 2064 WP_060388267.1 alpha-amylase -
AM470_RS25810 4952314..4952466 + 153 WP_019455508.1 hypothetical protein -
AM470_RS23775 4952468..4953445 - 978 WP_016929588.1 glyoxylate/hydroxypyruvate reductase GhrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-102)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14171.50 Da        Isoelectric Point: 7.3170

>T99186 WP_033649548.1 NZ_CP027533:c4948371-4947991 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIVWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T99186 NZ_CP027533:c4948371-4947991 [Serratia marcescens]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGTTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAACTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTGTCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTATCGGCTGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8607.55 Da        Isoelectric Point: 4.4791

>AT99186 WP_039568270.1 NZ_CP027533:c4948592-4948371 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHIPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Download         Length: 222 bp

>AT99186 NZ_CP027533:c4948592-4948371 [Serratia marcescens]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACATTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGACGGAGAACCACGTTGAAGATCCCAGCAATGCTTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4FS51

Antitoxin

Source ID Structure
AlphaFold DB A0A2S4X5L5

References