Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3618634..3619287 Replicon chromosome
Accession NZ_CP027530
Organism Acinetobacter baumannii strain AR_0088

Toxin (Protein)


Gene name cptA Uniprot ID A0A3R9G864
Locus tag AM467_RS17375 Protein ID WP_000607075.1
Coordinates 3618634..3619023 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag AM467_RS17380 Protein ID WP_001288210.1
Coordinates 3619030..3619287 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM467_RS17360 3613752..3615947 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
AM467_RS17365 3616135..3616701 - 567 WP_000651539.1 rhombosortase -
AM467_RS17370 3616779..3617864 - 1086 WP_000049105.1 hypothetical protein -
AM467_RS17375 3618634..3619023 - 390 WP_000607075.1 membrane protein Toxin
AM467_RS17380 3619030..3619287 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
AM467_RS17385 3619475..3620647 + 1173 WP_001190556.1 acyl-CoA dehydrogenase family protein -
AM467_RS17390 3620696..3622186 - 1491 WP_000415123.1 NAD(P)/FAD-dependent oxidoreductase -
AM467_RS17395 3622368..3622745 - 378 WP_001216380.1 50S ribosomal protein L17 -
AM467_RS17400 3622764..3623771 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.94 Da        Isoelectric Point: 10.3890

>T99167 WP_000607075.1 NZ_CP027530:c3619023-3618634 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLVEWKKLKTLEKLY

Download         Length: 390 bp

>T99167 NZ_CP027530:c3619023-3618634 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGTAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT99167 WP_001288210.1 NZ_CP027530:c3619287-3619030 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT99167 NZ_CP027530:c3619287-3619030 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCATTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R9G864

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References