Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1918131..1918609 Replicon chromosome
Accession NZ_CP027472
Organism Escherichia coli strain 2014C-3050

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag AAF93_RS10485 Protein ID WP_001303876.1
Coordinates 1918322..1918609 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag AAF93_RS10480 Protein ID WP_000536233.1
Coordinates 1918131..1918322 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AAF93_RS10445 1913536..1914306 - 771 WP_000450992.1 DUF1627 domain-containing protein -
AAF93_RS10450 1914328..1915074 - 747 WP_000788758.1 ATP-binding protein -
AAF93_RS10455 1915081..1916172 - 1092 WP_096850689.1 DNA-binding protein -
AAF93_RS10460 1916251..1916706 + 456 WP_000273724.1 hypothetical protein -
AAF93_RS10465 1916912..1917337 - 426 WP_000693855.1 Rha family transcriptional regulator -
AAF93_RS10470 1917321..1917593 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
AAF93_RS10475 1917702..1918103 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
AAF93_RS10480 1918131..1918322 + 192 WP_000536233.1 hypothetical protein Antitoxin
AAF93_RS10485 1918322..1918609 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AAF93_RS10490 1918886..1919041 + 156 WP_000379575.1 DUF1391 family protein -
AAF93_RS10500 1919183..1919572 + 390 WP_000394511.1 hypothetical protein -
AAF93_RS10505 1919759..1919944 - 186 WP_001133046.1 hypothetical protein -
AAF93_RS10515 1920518..1920706 + 189 WP_000413705.1 cell division inhibition protein DicB -
AAF93_RS10520 1920703..1920894 + 192 WP_001098307.1 DUF1482 family protein -
AAF93_RS10525 1920988..1923459 + 2472 WP_032278809.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - espM2 / espW 1852759..1949254 96495


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T99113 WP_001303876.1 NZ_CP027472:1918322-1918609 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T99113 NZ_CP027472:1918322-1918609 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT99113 WP_000536233.1 NZ_CP027472:1918131-1918322 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT99113 NZ_CP027472:1918131-1918322 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References