Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4309058..4310102 Replicon chromosome
Accession NZ_CP027462
Organism Escherichia coli isolate 07-4299

Toxin (Protein)


Gene name panT Uniprot ID A0A3W2VTW9
Locus tag C6W75_RS22395 Protein ID WP_000089360.1
Coordinates 4309058..4309606 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag C6W75_RS22400 Protein ID WP_000287252.1
Coordinates 4309629..4310102 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6W75_RS22360 4305065..4305427 + 363 WP_000135680.1 hypothetical protein -
C6W75_RS22365 4305493..4306317 + 825 WP_000081316.1 DUF2303 family protein -
C6W75_RS22370 4306445..4306981 + 537 WP_000008232.1 5'-deoxynucleotidase -
C6W75_RS22375 4306972..4307334 + 363 WP_001242725.1 hypothetical protein -
C6W75_RS22380 4307334..4308143 + 810 WP_000206746.1 hypothetical protein -
C6W75_RS22385 4308143..4308715 + 573 WP_001061343.1 3'-5' exoribonuclease -
C6W75_RS22390 4308752..4309024 + 273 WP_001093911.1 pyocin activator PrtN family protein -
C6W75_RS22395 4309058..4309606 - 549 WP_000089360.1 hypothetical protein Toxin
C6W75_RS22400 4309629..4310102 - 474 WP_000287252.1 SocA family protein Antitoxin
C6W75_RS22405 4310390..4310512 - 123 WP_001300034.1 hypothetical protein -
C6W75_RS22410 4310875..4311860 - 986 Protein_4106 DUF2713 domain-containing protein -
C6W75_RS22420 4312178..4312693 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
C6W75_RS22425 4312735..4312944 - 210 WP_001030593.1 CsbD family protein -
C6W75_RS22430 4313060..4314385 - 1326 WP_001301116.1 MATE family efflux transporter DinF -
C6W75_RS22435 4314458..4315066 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - stx2B / stx2A 4257991..4315544 57553


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20028.54 Da        Isoelectric Point: 4.6708

>T99092 WP_000089360.1 NZ_CP027462:c4309606-4309058 [Escherichia coli]
MSRNSDIYKLIGAAAGVENGRSEASLNYTDSQEQVFKSAFESSNHESDDGSSSENKAILEEEEFGSNTGALHEFMQQHRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVCFMSWWCLFVAVMFVSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDGDKEK

Download         Length: 549 bp

>T99092 NZ_CP027462:c4309606-4309058 [Escherichia coli]
ATGTCTCGCAATTCAGATATCTATAAACTTATCGGAGCGGCTGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTATACTGACAGTCAAGAACAGGTTTTTAAATCTGCATTTGAGTCGTCTAATCATGAGAGCGATGATGGTTCTTCTTCAG
AAAATAAAGCTATTCTGGAGGAAGAAGAGTTTGGCTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGCACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGCGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAACTTCGGACAAAAATGGCATCATTCACGGTTTGTTTTATGTCGTGGTGGTGCTTATTTGTAGCCGTAATGTTTG
TATCGTTTCTTATTGCTCATGAAGGAAAGCCTCCAGTTGAAGCAATCGTTGCATTACTGGGTACAAGTACAATTAGCATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATGGCGATAAAGAAAAATAA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT99092 WP_000287252.1 NZ_CP027462:c4310102-4309629 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp

>AT99092 NZ_CP027462:c4310102-4309629 [Escherichia coli]
ATGTACAGCCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAACGAATGTGTCTCTGCGT
GGAAGTACGGTCCGGTTATTCCCGGAATGTACGATGCTTTCAAAGATTATGGGAATAAGCCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATTGTTACTATGGATCCGCAAGCAGAGAGCATTATAGGGGCTGTTTATAAATTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCGA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3W2VTW9

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References