Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1280740..1281538 | Replicon | chromosome |
| Accession | NZ_CP027461 | ||
| Organism | Escherichia coli strain 95-3322 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A8T6QC23 |
| Locus tag | C6W78_RS06565 | Protein ID | WP_042022646.1 |
| Coordinates | 1281161..1281538 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0P7R0L9 |
| Locus tag | C6W78_RS06560 | Protein ID | WP_001285482.1 |
| Coordinates | 1280740..1281114 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C6W78_RS06520 | 1276755..1277210 | + | 456 | WP_000581502.1 | hypothetical protein | - |
| C6W78_RS26605 | 1277329..1277540 | - | 212 | Protein_1191 | hypothetical protein | - |
| C6W78_RS06530 | 1277621..1278442 | + | 822 | WP_044694629.1 | DUF945 domain-containing protein | - |
| C6W78_RS06535 | 1278442..1278687 | + | 246 | WP_001164966.1 | hypothetical protein | - |
| C6W78_RS06540 | 1278781..1279251 | + | 471 | WP_016232931.1 | antirestriction protein | - |
| C6W78_RS06545 | 1279267..1279743 | + | 477 | WP_001439314.1 | RadC family protein | - |
| C6W78_RS06550 | 1279806..1280027 | + | 222 | WP_000692315.1 | DUF987 domain-containing protein | - |
| C6W78_RS06555 | 1280046..1280690 | + | 645 | WP_000086759.1 | hypothetical protein | - |
| C6W78_RS06560 | 1280740..1281114 | + | 375 | WP_001285482.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| C6W78_RS06565 | 1281161..1281538 | + | 378 | WP_042022646.1 | TA system toxin CbtA family protein | Toxin |
| C6W78_RS06570 | 1281535..1282038 | + | 504 | WP_061335745.1 | hypothetical protein | - |
| C6W78_RS06575 | 1282035..1282232 | + | 198 | WP_042022639.1 | DUF957 domain-containing protein | - |
| C6W78_RS06580 | 1282329..1283156 | + | 828 | WP_187440709.1 | DUF4942 domain-containing protein | - |
| C6W78_RS06590 | 1283642..1284580 | + | 939 | WP_021580656.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| C6W78_RS06595 | 1284635..1285372 | + | 738 | WP_000283664.1 | zinc-binding phosphatase | - |
| C6W78_RS06600 | 1285396..1285950 | + | 555 | WP_001001921.1 | molecular chaperone YcdY | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | csgG / csgF / csgE / csgD / csgB / csgA / csgC | 1257225..1291482 | 34257 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14061.07 Da Isoelectric Point: 7.8044
>T99052 WP_042022646.1 NZ_CP027461:1281161-1281538 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMVRDNYRTVNNITLGKHPGAKQ
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMVRDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T99052 NZ_CP027461:1281161-1281538 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGTCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGTCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13791.44 Da Isoelectric Point: 4.7511
>AT99052 WP_001285482.1 NZ_CP027461:1280740-1281114 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
Download Length: 375 bp
>AT99052 NZ_CP027461:1280740-1281114 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|