Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2183996..2184477 Replicon chromosome
Accession NZ_CP027459
Organism Escherichia coli strain 90-3040

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag C6W76_RS12200 Protein ID WP_021568727.1
Coordinates 2184187..2184477 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID -
Locus tag C6W76_RS12195 Protein ID WP_000108762.1
Coordinates 2183996..2184187 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6W76_RS12150 2179323..2179427 - 105 WP_001278459.1 hypothetical protein -
C6W76_RS12155 2179537..2180370 - 834 WP_032206192.1 hypothetical protein -
C6W76_RS12160 2180406..2180618 - 213 WP_032206194.1 hypothetical protein -
C6W76_RS12165 2180664..2181023 - 360 WP_032206196.1 hypothetical protein -
C6W76_RS12170 2181077..2181502 - 426 WP_047087727.1 DUF977 family protein -
C6W76_RS12175 2181543..2182613 - 1071 WP_106888131.1 phage replisome organizer -
C6W76_RS12180 2182685..2183110 - 426 WP_000693918.1 Rha family transcriptional regulator -
C6W76_RS12185 2183107..2183370 - 264 WP_001048459.1 helix-turn-helix domain-containing protein -
C6W76_RS12190 2183478..2183978 + 501 WP_021568728.1 helix-turn-helix transcriptional regulator -
C6W76_RS12195 2183996..2184187 + 192 WP_000108762.1 hypothetical protein Antitoxin
C6W76_RS12200 2184187..2184477 + 291 WP_021568727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6W76_RS12205 2184752..2184904 + 153 WP_000367377.1 DUF1391 family protein -
C6W76_RS12210 2185003..2185449 - 447 WP_000373334.1 hypothetical protein -
C6W76_RS12220 2186162..2186350 + 189 WP_000413705.1 cell division inhibition protein DicB -
C6W76_RS12225 2186347..2186538 + 192 WP_001098307.1 DUF1482 family protein -
C6W76_RS12230 2186632..2189107 + 2476 Protein_2245 3'-5' exoribonuclease -
C6W76_RS12235 2189175..2189378 + 204 WP_099357990.1 DUF4224 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2146510..2194434 47924


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11105.96 Da        Isoelectric Point: 9.9854

>T99035 WP_021568727.1 NZ_CP027459:2184187-2184477 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLSEHPYLYPPSERALGLREIVTHPNYIILYRVTASNIE
IVNVVHSRRQYPNKSC

Download         Length: 291 bp

>T99035 NZ_CP027459:2184187-2184477 [Escherichia coli]
ATGCTGCCCATTTTATGGCTACCTTCTGCGCGTGATGATTTGCGTCAGATCGTAGCCTATATTGCCAAGGAAAACCCTCC
CGCTGCACGTAGACTAAAAATACGCATTGAAACATCAGTTTTGTCACTTTCTGAACATCCTTACCTGTATCCACCAAGCG
AAAGAGCTCTAGGCCTTCGTGAGATAGTGACCCATCCTAACTACATAATACTTTACCGAGTAACAGCATCTAACATCGAG
ATCGTAAATGTAGTTCACTCACGAAGGCAGTATCCAAACAAAAGCTGTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7075.91 Da        Isoelectric Point: 4.0270

>AT99035 WP_000108762.1 NZ_CP027459:2183996-2184187 [Escherichia coli]
MSTVLSPIISEFETIEQENSYNEWLRTKVAASLADPRPAIPHDEVMAEMENLIAQIASTNRSE

Download         Length: 192 bp

>AT99035 NZ_CP027459:2183996-2184187 [Escherichia coli]
ATGAGTACAGTCCTTTCCCCGATAATTTCAGAATTTGAAACAATCGAACAAGAAAACAGCTATAACGAATGGTTACGCAC
CAAAGTGGCAGCAAGCCTCGCAGACCCCCGTCCTGCAATTCCGCATGACGAAGTAATGGCTGAAATGGAAAACCTTATTG
CGCAAATAGCTTCGACGAACAGGAGTGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References