Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5065138..5065922 Replicon chromosome
Accession NZ_CP027454
Organism Escherichia coli strain 2014C-4423

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag C6W74_RS26835 Protein ID WP_032209850.1
Coordinates 5065596..5065922 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag C6W74_RS26830 Protein ID WP_001285487.1
Coordinates 5065138..5065506 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6W74_RS26790 5061014..5061187 - 174 Protein_4905 N-acetyltransferase -
C6W74_RS26795 5061678..5061884 + 207 WP_000632607.1 AlpA family transcriptional regulator -
C6W74_RS26800 5061983..5063160 + 1178 WP_085968792.1 IS3 family transposase -
C6W74_RS26805 5063166..5063474 + 309 Protein_4908 DUF932 domain-containing protein -
C6W74_RS26810 5063474..5063719 + 246 WP_032212706.1 hypothetical protein -
C6W74_RS26815 5063813..5064286 + 474 WP_000855068.1 antirestriction protein -
C6W74_RS26820 5064302..5064778 + 477 WP_001186728.1 RadC family protein -
C6W74_RS26825 5064841..5065062 + 222 WP_000692312.1 DUF987 domain-containing protein -
C6W74_RS26830 5065138..5065506 + 369 WP_001285487.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C6W74_RS26835 5065596..5065922 + 327 WP_032209850.1 TA system toxin CbtA family protein Toxin
C6W74_RS26840 5065970..5066458 + 489 WP_000761730.1 hypothetical protein -
C6W74_RS26845 5066470..5066667 + 198 WP_000839243.1 DUF957 domain-containing protein -
C6W74_RS26850 5066752..5067594 + 843 WP_024174205.1 DUF4942 domain-containing protein -
C6W74_RS26855 5067937..5068473 - 537 WP_000942788.1 GspM family type II secretion system protein YghD -
C6W74_RS26860 5068475..5069653 - 1179 WP_000094965.1 type II secretion system protein GspL -
C6W74_RS26865 5069650..5070627 - 978 WP_000633206.1 type II secretion system minor pseudopilin GspK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - espK / espF / escG / escF / cesD2 / espB / espD / espA / sepL / escD / eae / cesT / tir / map / cesF / espH / sepQ/escQ / escO / escN / escV / cesL / escI / escJ / sepD / escC / cesD / etgA / escU / escT / escS / escR / escL / escK / cesAB / escE / espG / gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD 5002744..5077409 74665


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12204.95 Da        Isoelectric Point: 6.4697

>T98984 WP_032209850.1 NZ_CP027454:5065596-5065922 [Escherichia coli]
MKTLPDTHVREASRCPSPVIIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDN

Download         Length: 327 bp

>T98984 NZ_CP027454:5065596-5065922 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCATCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACTCGCGA
CAATTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13737.53 Da        Isoelectric Point: 5.4844

>AT98984 WP_001285487.1 NZ_CP027454:5065138-5065506 [Escherichia coli]
VSDTLHETNYPNDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT98984 NZ_CP027454:5065138-5065506 [Escherichia coli]
GTGTCAGACACACTCCATGAGACAAATTATCCCAACGACAATCACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References