Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2560890..2561368 Replicon chromosome
Accession NZ_CP027454
Organism Escherichia coli strain 2014C-4423

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag C6W74_RS13175 Protein ID WP_001303876.1
Coordinates 2560890..2561177 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag C6W74_RS13180 Protein ID WP_000536233.1
Coordinates 2561177..2561368 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6W74_RS13135 2556040..2558511 - 2472 WP_000034468.1 exonuclease -
C6W74_RS13140 2558605..2558796 - 192 WP_001098307.1 DUF1482 family protein -
C6W74_RS13145 2558793..2558981 - 189 WP_000413705.1 cell division inhibition protein DicB -
C6W74_RS13155 2559555..2559740 + 186 WP_001133046.1 hypothetical protein -
C6W74_RS13160 2559927..2560316 - 390 WP_000394511.1 hypothetical protein -
C6W74_RS13170 2560458..2560613 - 156 WP_000379575.1 DUF1391 family protein -
C6W74_RS13175 2560890..2561177 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6W74_RS13180 2561177..2561368 - 192 WP_000536233.1 hypothetical protein Antitoxin
C6W74_RS13185 2561396..2561797 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
C6W74_RS13190 2561906..2562178 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
C6W74_RS13195 2562162..2562587 + 426 WP_000693855.1 Rha family transcriptional regulator -
C6W74_RS13200 2562794..2563249 - 456 WP_000273724.1 hypothetical protein -
C6W74_RS13205 2563328..2564453 + 1126 Protein_2390 DNA-binding protein -
C6W74_RS13210 2564450..2565190 + 741 WP_000788752.1 ATP-binding protein -
C6W74_RS13215 2565216..2565986 + 771 WP_000450862.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T98963 WP_001303876.1 NZ_CP027454:c2561177-2560890 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T98963 NZ_CP027454:c2561177-2560890 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT98963 WP_000536233.1 NZ_CP027454:c2561368-2561177 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT98963 NZ_CP027454:c2561368-2561177 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References