Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 1665182..1666226 Replicon chromosome
Accession NZ_CP027452
Organism Escherichia coli strain 2014C-3338

Toxin (Protein)


Gene name panT Uniprot ID A0A3W2VTW9
Locus tag C6W71_RS08735 Protein ID WP_000089360.1
Coordinates 1665182..1665730 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag C6W71_RS08740 Protein ID WP_000287252.1
Coordinates 1665753..1666226 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6W71_RS08700 1661189..1661551 + 363 WP_000135680.1 hypothetical protein -
C6W71_RS08705 1661617..1662441 + 825 WP_106889415.1 DUF2303 family protein -
C6W71_RS08710 1662569..1663105 + 537 WP_000008232.1 5'-deoxynucleotidase -
C6W71_RS08715 1663096..1663458 + 363 WP_001242725.1 hypothetical protein -
C6W71_RS08720 1663458..1664267 + 810 WP_000206746.1 hypothetical protein -
C6W71_RS08725 1664267..1664839 + 573 WP_001061343.1 3'-5' exoribonuclease -
C6W71_RS08730 1664876..1665148 + 273 WP_001093911.1 pyocin activator PrtN family protein -
C6W71_RS08735 1665182..1665730 - 549 WP_000089360.1 hypothetical protein Toxin
C6W71_RS08740 1665753..1666226 - 474 WP_000287252.1 SocA family protein Antitoxin
C6W71_RS08745 1666750..1667265 + 516 WP_000416264.1 zinc uptake transcriptional repressor Zur -
C6W71_RS08750 1667307..1667516 - 210 WP_001296638.1 CsbD family protein -
C6W71_RS08755 1667632..1668957 - 1326 WP_001318177.1 MATE family efflux transporter DinF -
C6W71_RS08760 1669030..1669638 - 609 WP_000646078.1 transcriptional repressor LexA -
C6W71_RS08765 1669748..1670116 - 369 WP_000002907.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - stx2B / stx2A 1616517..1669638 53121


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20028.54 Da        Isoelectric Point: 4.6708

>T98933 WP_000089360.1 NZ_CP027452:c1665730-1665182 [Escherichia coli]
MSRNSDIYKLIGAAAGVENGRSEASLNYTDSQEQVFKSAFESSNHESDDGSSSENKAILEEEEFGSNTGALHEFMQQHRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVCFMSWWCLFVAVMFVSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDGDKEK

Download         Length: 549 bp

>T98933 NZ_CP027452:c1665730-1665182 [Escherichia coli]
ATGTCTCGCAATTCAGATATCTATAAACTTATCGGAGCGGCTGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTATACTGACAGTCAAGAACAGGTTTTTAAATCTGCATTTGAGTCGTCTAATCATGAGAGCGATGATGGTTCTTCTTCAG
AAAATAAAGCTATTCTGGAGGAAGAAGAGTTTGGCTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGCACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGCGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAACTTCGGACAAAAATGGCATCATTCACGGTTTGTTTTATGTCGTGGTGGTGCTTATTTGTAGCCGTAATGTTTG
TATCGTTTCTTATTGCTCATGAAGGAAAGCCTCCAGTTGAAGCAATCGTTGCATTACTGGGTACAAGTACAATTAGCATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATGGCGATAAAGAAAAATAA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT98933 WP_000287252.1 NZ_CP027452:c1666226-1665753 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp

>AT98933 NZ_CP027452:c1666226-1665753 [Escherichia coli]
ATGTACAGCCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAACGAATGTGTCTCTGCGT
GGAAGTACGGTCCGGTTATTCCCGGAATGTACGATGCTTTCAAAGATTATGGGAATAAGCCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATTGTTACTATGGATCCGCAAGCAGAGAGCATTATAGGGGCTGTTTATAAATTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCGA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3W2VTW9

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References