Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2335746..2336449 Replicon chromosome
Accession NZ_CP027445
Organism Escherichia coli strain 2013C-3492

Toxin (Protein)


Gene name ypjF Uniprot ID A0A8T6BCS1
Locus tag C6W68_RS12830 Protein ID WP_001616568.1
Coordinates 2335746..2336087 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag C6W68_RS12835 Protein ID WP_032208435.1
Coordinates 2336108..2336449 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6W68_RS12800 2331161..2332141 + 981 WP_032208436.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
C6W68_RS12805 2332149..2332271 - 123 WP_001300013.1 hypothetical protein -
C6W68_RS12815 2332663..2333849 - 1187 Protein_2344 IS3-like element IS2 family transposase -
C6W68_RS12825 2334491..2335498 - 1008 WP_001616572.1 restriction endonuclease -
C6W68_RS12830 2335746..2336087 - 342 WP_001616568.1 TA system toxin CbtA family protein Toxin
C6W68_RS12835 2336108..2336449 - 342 WP_032208435.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C6W68_RS12840 2336460..2337002 - 543 WP_001616564.1 DNA repair protein RadC -
C6W68_RS12845 2337015..2337455 - 441 WP_001616563.1 antirestriction protein -
C6W68_RS12850 2337486..2338307 - 822 WP_032208434.1 DUF945 domain-containing protein -
C6W68_RS12855 2338405..2338635 - 231 WP_072057388.1 DUF905 domain-containing protein -
C6W68_RS12860 2338705..2339154 - 450 WP_032208432.1 hypothetical protein -
C6W68_RS12865 2339151..2339606 - 456 WP_032208430.1 hypothetical protein -
C6W68_RS12870 2339645..2340280 - 636 WP_001616559.1 hypothetical protein -
C6W68_RS12875 2340277..2340990 - 714 WP_032208428.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12746.75 Da        Isoelectric Point: 9.6548

>T98844 WP_001616568.1 NZ_CP027445:c2336087-2335746 [Escherichia coli]
MKTLPATTPQAAKLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

>T98844 NZ_CP027445:c2336087-2335746 [Escherichia coli]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGAAGCTATGTCTGTCGCCCGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACGCCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCGGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTAAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12827.46 Da        Isoelectric Point: 6.4660

>AT98844 WP_032208435.1 NZ_CP027445:c2336449-2336108 [Escherichia coli]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFSEAECLRLDVAFPHFISQMESMLTTGEMNPRH
AHCVTLYYNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp

>AT98844 NZ_CP027445:c2336449-2336108 [Escherichia coli]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTCAGCGAAGCAGAATGTC
TTAGGCTGGATGTGGCATTCCCACATTTTATCAGCCAGATGGAGTCGATGTTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTGTGTCACCCTGTACTACAATGGTTTCACCTGCGAAGCCGATACCCTTGGTAGTTACGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References