Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1080756..1081237 Replicon chromosome
Accession NZ_CP027445
Organism Escherichia coli strain 2013C-3492

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag C6W68_RS06220 Protein ID WP_021568727.1
Coordinates 1080947..1081237 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID -
Locus tag C6W68_RS06215 Protein ID WP_000108762.1
Coordinates 1080756..1080947 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6W68_RS06170 1076083..1076187 - 105 WP_001278459.1 hypothetical protein -
C6W68_RS06175 1076297..1077130 - 834 WP_032206192.1 hypothetical protein -
C6W68_RS06180 1077166..1077378 - 213 WP_032206194.1 hypothetical protein -
C6W68_RS06185 1077424..1077783 - 360 WP_032206196.1 hypothetical protein -
C6W68_RS06190 1077837..1078262 - 426 WP_047087727.1 DUF977 family protein -
C6W68_RS06195 1078303..1079373 - 1071 WP_106888131.1 phage replisome organizer -
C6W68_RS06200 1079445..1079870 - 426 WP_000693918.1 Rha family transcriptional regulator -
C6W68_RS06205 1079867..1080130 - 264 WP_001048459.1 helix-turn-helix domain-containing protein -
C6W68_RS06210 1080238..1080738 + 501 WP_021568728.1 helix-turn-helix transcriptional regulator -
C6W68_RS06215 1080756..1080947 + 192 WP_000108762.1 hypothetical protein Antitoxin
C6W68_RS06220 1080947..1081237 + 291 WP_021568727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6W68_RS06225 1081512..1081664 + 153 WP_000367377.1 DUF1391 family protein -
C6W68_RS06230 1081763..1082209 - 447 WP_000373334.1 hypothetical protein -
C6W68_RS06240 1082922..1083110 + 189 WP_000413705.1 cell division inhibition protein DicB -
C6W68_RS06245 1083107..1083298 + 192 WP_001098307.1 DUF1482 family protein -
C6W68_RS06250 1083392..1085867 + 2476 Protein_1151 3'-5' exoribonuclease -
C6W68_RS06255 1085935..1086138 + 204 WP_099357990.1 DUF4224 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 995952..1089707 93755


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11105.96 Da        Isoelectric Point: 9.9854

>T98840 WP_021568727.1 NZ_CP027445:1080947-1081237 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLSEHPYLYPPSERALGLREIVTHPNYIILYRVTASNIE
IVNVVHSRRQYPNKSC

Download         Length: 291 bp

>T98840 NZ_CP027445:1080947-1081237 [Escherichia coli]
ATGCTGCCCATTTTATGGCTACCTTCTGCGCGTGATGATTTGCGTCAGATCGTAGCCTATATTGCCAAGGAAAACCCTCC
CGCTGCACGTAGACTAAAAATACGCATTGAAACATCAGTTTTGTCACTTTCTGAACATCCTTACCTGTATCCACCAAGCG
AAAGAGCTCTAGGCCTTCGTGAGATAGTGACCCATCCTAACTACATAATACTTTACCGAGTAACAGCATCTAACATCGAG
ATCGTAAATGTAGTTCACTCACGAAGGCAGTATCCAAACAAAAGCTGTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7075.91 Da        Isoelectric Point: 4.0270

>AT98840 WP_000108762.1 NZ_CP027445:1080756-1080947 [Escherichia coli]
MSTVLSPIISEFETIEQENSYNEWLRTKVAASLADPRPAIPHDEVMAEMENLIAQIASTNRSE

Download         Length: 192 bp

>AT98840 NZ_CP027445:1080756-1080947 [Escherichia coli]
ATGAGTACAGTCCTTTCCCCGATAATTTCAGAATTTGAAACAATCGAACAAGAAAACAGCTATAACGAATGGTTACGCAC
CAAAGTGGCAGCAAGCCTCGCAGACCCCCGTCCTGCAATTCCGCATGACGAAGTAATGGCTGAAATGGAAAACCTTATTG
CGCAAATAGCTTCGACGAACAGGAGTGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References