Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 685506..686032 | Replicon | chromosome |
| Accession | NZ_CP027442 | ||
| Organism | Escherichia coli strain 2013C-3252 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | MJ69_RS04260 | Protein ID | WP_000323025.1 |
| Coordinates | 685506..685793 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | MJ69_RS04265 | Protein ID | WP_000534858.1 |
| Coordinates | 685793..686032 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MJ69_RS04220 | 680530..680745 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| MJ69_RS32530 | 680965..681135 | + | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| MJ69_RS04225 | 681499..681714 | - | 216 | WP_000066483.1 | cold shock-like protein CspB | - |
| MJ69_RS04230 | 682015..682227 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| MJ69_RS31950 | 682282..682371 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| MJ69_RS04235 | 682649..683401 | - | 753 | WP_001047133.1 | antitermination protein | - |
| MJ69_RS04240 | 683415..684464 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| MJ69_RS04245 | 684466..684744 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| MJ69_RS04250 | 684811..685062 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| MJ69_RS04255 | 685279..685434 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| MJ69_RS04260 | 685506..685793 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| MJ69_RS04265 | 685793..686032 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| MJ69_RS04270 | 686057..686362 | + | 306 | WP_001326990.1 | hypothetical protein | - |
| MJ69_RS04275 | 686565..686897 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| MJ69_RS04280 | 687334..688674 | - | 1341 | WP_000589012.1 | ISNCY family transposase | - |
| MJ69_RS04285 | 688708..689127 | - | 420 | WP_001151195.1 | DUF977 family protein | - |
| MJ69_RS04290 | 689168..690133 | - | 966 | WP_000054507.1 | hypothetical protein | - |
| MJ69_RS04295 | 690114..690635 | - | 522 | WP_000705349.1 | hypothetical protein | - |
| MJ69_RS04300 | 690619..690846 | - | 228 | WP_000476993.1 | transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | espFu/tccP | 556010..713051 | 157041 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T98810 WP_000323025.1 NZ_CP027442:c685793-685506 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T98810 NZ_CP027442:c685793-685506 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT98810 WP_000534858.1 NZ_CP027442:c686032-685793 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT98810 NZ_CP027442:c686032-685793 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|