Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 21654..22189 Replicon plasmid unnamed2
Accession NZ_CP027439
Organism Escherichia coli strain 2012C-4221

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag C6W65_RS26100 Protein ID WP_000222786.1
Coordinates 21654..21941 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag C6W65_RS26105 Protein ID WP_001120171.1
Coordinates 21938..22189 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6W65_RS26065 18130..18441 + 312 WP_078405668.1 hypothetical protein -
C6W65_RS26070 18602..19003 + 402 WP_000171282.1 hypothetical protein -
C6W65_RS27080 19121..19450 + 330 WP_001334906.1 hypothetical protein -
C6W65_RS26080 19646..19903 + 258 WP_106907072.1 hypothetical protein -
C6W65_RS26085 19999..20445 - 447 WP_000616196.1 hypothetical protein -
C6W65_RS26090 20563..21042 + 480 WP_106907074.1 peptidase M14 -
C6W65_RS26095 21294..21491 + 198 WP_077631139.1 AraC family transcriptional regulator -
C6W65_RS26100 21654..21941 - 288 WP_000222786.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6W65_RS26105 21938..22189 - 252 WP_001120171.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C6W65_RS26110 22413..22952 + 540 WP_106907077.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
C6W65_RS26115 23338..24204 + 867 WP_000172786.1 AAA family ATPase -
C6W65_RS26120 24204..25235 + 1032 WP_106907079.1 ParB/RepB/Spo0J family partition protein -
C6W65_RS26125 25235..25672 + 438 WP_000843285.1 hypothetical protein -
C6W65_RS26970 25669..25992 + 324 WP_153645668.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - acrB / vat 1..107188 107188


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11130.06 Da        Isoelectric Point: 10.5077

>T98775 WP_000222786.1 NZ_CP027439:c21941-21654 [Escherichia coli]
MTYTVRFREDALKEWQKLDKAIQQQFAKKLKKCSENPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDDQLVIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

>T98775 NZ_CP027439:c21941-21654 [Escherichia coli]
ATGACTTACACAGTCAGATTCAGGGAAGATGCACTGAAAGAATGGCAAAAACTGGATAAGGCAATTCAGCAGCAGTTTGC
TAAAAAGCTAAAGAAGTGCAGTGAAAATCCACATATCCCATCAGCAAAACTGCGTGGGATAAAGGATTGCTACAAAATTA
AACTTCGTGCGTCTGGCTTCCGCCTGGTTTATCAGGTGATTGATGATCAATTAGTTATCGCTGTTGTTGCTGTAGGGAAA
CGTGAACGTAGTGATGTTTATAATCTTGCCAGCGAACGAATGAGGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9193.40 Da        Isoelectric Point: 4.2101

>AT98775 WP_001120171.1 NZ_CP027439:c22189-21938 [Escherichia coli]
MPHIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYEKMLDALDDQELVNLVAERSNQKLHDVDLD
SYL

Download         Length: 252 bp

>AT98775 NZ_CP027439:c22189-21938 [Escherichia coli]
ATGCCCCACATTATTCTGAGTGACACTAGCGCCAGTGTCAGCGAACTGAAAAAAAACCCGATGGCGACAGTCAGTGCCGG
TGATGGTTACCCAGTCGCGATTCTGAACCGTAACCAGCCCGCCTTTTACTGTGTCCCCGCAGAACTGTATGAAAAGATGC
TCGATGCCCTAGACGATCAGGAACTGGTTAATCTGGTCGCCGAACGCAGCAACCAGAAGCTGCACGATGTAGATCTGGAT
AGCTACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References