Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2024131..2024609 Replicon chromosome
Accession NZ_CP027435
Organism Escherichia coli strain 2014C-3599

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ND02_RS10340 Protein ID WP_001303876.1
Coordinates 2024131..2024418 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ND02_RS10345 Protein ID WP_000536233.1
Coordinates 2024418..2024609 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND02_RS10300 2019281..2021752 - 2472 WP_000034468.1 exonuclease -
ND02_RS10305 2021846..2022037 - 192 WP_001098307.1 DUF1482 family protein -
ND02_RS10310 2022034..2022222 - 189 WP_000413705.1 cell division inhibition protein DicB -
ND02_RS10320 2022796..2022981 + 186 WP_001133046.1 hypothetical protein -
ND02_RS10325 2023168..2023557 - 390 WP_000394511.1 hypothetical protein -
ND02_RS10335 2023699..2023854 - 156 WP_000379575.1 DUF1391 family protein -
ND02_RS10340 2024131..2024418 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ND02_RS10345 2024418..2024609 - 192 WP_000536233.1 hypothetical protein Antitoxin
ND02_RS10350 2024637..2025038 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ND02_RS10355 2025147..2025419 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ND02_RS10360 2025403..2025828 + 426 WP_000693855.1 Rha family transcriptional regulator -
ND02_RS10365 2026035..2026490 - 456 WP_000273724.1 hypothetical protein -
ND02_RS10370 2026569..2027693 + 1125 WP_072097015.1 DNA-binding protein -
ND02_RS10375 2027690..2028430 + 741 WP_000788752.1 ATP-binding protein -
ND02_RS10380 2028456..2029226 + 771 WP_000450862.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T98718 WP_001303876.1 NZ_CP027435:c2024418-2024131 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T98718 NZ_CP027435:c2024418-2024131 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT98718 WP_000536233.1 NZ_CP027435:c2024609-2024418 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT98718 NZ_CP027435:c2024609-2024418 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References