Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3187260..3187914 Replicon chromosome
Accession NZ_CP027430
Organism Escherichia coli strain AS19-RrmA-

Toxin (Protein)


Gene name cptA Uniprot ID A0A140N853
Locus tag C6P57_RS16615 Protein ID WP_000244783.1
Coordinates 3187507..3187914 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag C6P57_RS16610 Protein ID WP_000354046.1
Coordinates 3187260..3187526 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6P57_RS16585 3182429..3183172 + 744 WP_000951948.1 SDR family oxidoreductase -
C6P57_RS16590 3183229..3184662 - 1434 WP_012775976.1 6-phospho-beta-glucosidase BglA -
C6P57_RS16595 3184707..3185018 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
C6P57_RS16600 3185182..3185841 + 660 WP_000250274.1 hemolysin III family protein -
C6P57_RS16605 3186037..3187017 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
C6P57_RS16610 3187260..3187526 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
C6P57_RS16615 3187507..3187914 + 408 WP_000244783.1 protein YgfX Toxin
C6P57_RS16620 3187954..3188475 - 522 WP_001055874.1 flavodoxin FldB -
C6P57_RS16625 3188587..3189483 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
C6P57_RS16630 3189508..3190218 + 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C6P57_RS16635 3190224..3191957 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15962.85 Da        Isoelectric Point: 11.2669

>T98698 WP_000244783.1 NZ_CP027430:3187507-3187914 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEISLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T98698 NZ_CP027430:3187507-3187914 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTAGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT98698 WP_000354046.1 NZ_CP027430:3187260-3187526 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT98698 NZ_CP027430:3187260-3187526 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A140N853

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References