Detailed information of TA system TA098697

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3110328..3111160
• Replicon: chromosome
• Accession: NZ_CP027430
• Organism: Escherichia coli strain AS19-RrmA-

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A3P5UBZ5
• Locus tag: C6P57_RS16190
• Protein ID: WP_001094454.1
• Coordinates: 3110328..3110702 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A3G8RJV8
• Locus tag: C6P57_RS16195
• Protein ID: WP_001320394.1
• Coordinates: 3110792..3111160 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6P57_RS16160	3105441..3106589	-	1149	WP_000905931.1	capsule polysaccharide export inner-membrane protein KpsE	-
C6P57_RS16165	3106661..3107644	-	984	WP_024181915.1	KpsF/GutQ family sugar-phosphate isomerase	-
C6P57_RS16170	3108455..3108625	-	171	Protein_2922	IS110 family transposase	-
C6P57_RS16175	3108968..3109537	-	570	WP_001290250.1	DUF4942 domain-containing protein	-
C6P57_RS16180	3109634..3109831	-	198	WP_000839276.1	DUF957 domain-containing protein	-
C6P57_RS16185	3109843..3110331	-	489	WP_000777545.1	hypothetical protein	-
C6P57_RS16190	3110328..3110702	-	375	WP_001094454.1	TA system toxin CbtA family protein	Toxin
C6P57_RS16195	3110792..3111160	-	369	WP_001320394.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
C6P57_RS16200	3111210..3111853	-	644	Protein_2928	antitoxin of toxin-antitoxin stability system	-
C6P57_RS16205	3111872..3112093	-	222	WP_000692300.1	DUF987 domain-containing protein	-
C6P57_RS16210	3112156..3112632	-	477	WP_001347688.1	RadC family protein	-
C6P57_RS24080	3112648..3112821	-	174	Protein_2931	antirestriction protein	-
C6P57_RS16215	3112819..3114519	-	1701	Protein_2932	autotransporter adhesin family protein	-
C6P57_RS16220	3114891..3115763	-	873	WP_001322100.1	GTPase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14059.10 Da
• Isoelectric Point: 9.2447

>T98697 WP_001094454.1 NZ_CP027430:c3110702-3110328 [Escherichia coli]
MNTLPDTHVRKASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Nucleotide

• Length: 375 bp

>T98697 NZ_CP027430:c3110702-3110328 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGAAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13623.22 Da
• Isoelectric Point: 6.4783

>AT98697 WP_001320394.1 NZ_CP027430:c3111160-3110792 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ

Nucleotide

• Length: 369 bp

>AT98697 NZ_CP027430:c3111160-3110792 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCAGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAAGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA

Structures

Toxin

• AlphaFold DB: A0A3P5UBZ5

Antitoxin

• AlphaFold DB: A0A3G8RJV8