Detailed information of TA system TA098693

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 1615965..1616779
• Replicon: chromosome
• Accession: NZ_CP027430
• Organism: Escherichia coli strain AS19-RrmA-

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: C6P57_RS08510
• Protein ID: WP_001054376.1
• Coordinates: 1615965..1616222 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: C6P57_RS08515
• Protein ID: WP_001309181.1
• Coordinates: 1616234..1616779 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6P57_RS08480	1611253..1612359	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
C6P57_RS08485	1612424..1613404	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
C6P57_RS08490	1613987..1615227	-	1241	Protein_1544	helicase YjhR	-
C6P57_RS08500	1615343..1615588	+	246	Protein_1545	GNAT family N-acetyltransferase	-
C6P57_RS08510	1615965..1616222	+	258	WP_001054376.1	hypothetical protein	Toxin
C6P57_RS08515	1616234..1616779	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
C6P57_RS08520	1616835..1617581	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
C6P57_RS08525	1617750..1617968	+	219	Protein_1549	hypothetical protein	-
C6P57_RS24065	1618006..1618122	+	117	Protein_1550	VOC family protein	-
C6P57_RS08530	1618367..1619488	+	1122	WP_000010829.1	M42 family metallopeptidase	-
C6P57_RS08535	1619485..1619763	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
C6P57_RS08540	1619775..1621088	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	fimE / fimB	1606609..1658368	51759

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T98693 WP_001054376.1 NZ_CP027430:1615965-1616222 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T98693 NZ_CP027430:1615965-1616222 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT98693 WP_001309181.1 NZ_CP027430:1616234-1616779 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT98693 NZ_CP027430:1616234-1616779 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8