98689

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1049501..1050119 Replicon chromosome
Accession NZ_CP027430
Organism Escherichia coli strain AS19-RrmA-

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag C6P57_RS05625 Protein ID WP_001291435.1
Coordinates 1049901..1050119 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag C6P57_RS05620 Protein ID WP_000344800.1
Coordinates 1049501..1049875 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6P57_RS05610 1044591..1045802 + 1212 WP_105929187.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
C6P57_RS05615 1045806..1048955 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
C6P57_RS05620 1049501..1049875 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
C6P57_RS05625 1049901..1050119 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
C6P57_RS05630 1050291..1050842 + 552 WP_000102564.1 maltose O-acetyltransferase -
C6P57_RS05635 1050958..1051428 + 471 WP_000136192.1 YlaC family protein -
C6P57_RS05640 1051592..1053142 + 1551 WP_001319841.1 cyclic-guanylate-specific phosphodiesterase PdeB -
C6P57_RS05645 1053184..1053537 - 354 WP_000878140.1 DUF1428 domain-containing protein -
C6P57_RS05655 1053916..1054227 + 312 WP_000409911.1 MGMT family protein -
C6P57_RS05660 1054258..1054830 - 573 WP_000779826.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T98689 WP_001291435.1 NZ_CP027430:1049901-1050119 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T98689 NZ_CP027430:1049901-1050119 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT98689 WP_000344800.1 NZ_CP027430:1049501-1049875 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT98689 NZ_CP027430:1049501-1049875 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References